Abstract
IN mouse nerve iso- and allografts, Schwann cells transplanted from the donor animal survive, multiply within the graft and, eventually, ensheath axons regenerating from the host nerve1–3. This demonstration of the persistence of donor cells in nerve grafts has made possible the in vivo study of cell interactions in genetically-determined animal neuropathies. By combining normal and abnormal nerves, each originating from different strains of mice, a primary Schwann cell abnormality has been demonstrated in Trembler3 and Quaking4 mutant mice while axonal factors seem to be responsible for changes in the spinal roots of dystrophic mice5,6. We report here the successful transplantation into immunologically-suppressed mice of human Schwann cells from control patients and from the sural nerve of a child with metachromatic leukodystrophy. Metachromatic leukodystrophy (MLD) is a human autosomal recessive disease due to aryl sulphatase deficiency and characterised by degeneration in the central and peripheral nervous systems with intracellular accumulations of metachromatic granules7,8.
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AGUAYO, A., KASARJIAN, J., SKAMENE, E. et al. Myelination of mouse axons by Schwann cells transplanted from normal and abnormal human nerves. Nature 268, 753–755 (1977). https://doi.org/10.1038/268753a0
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DOI: https://doi.org/10.1038/268753a0
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