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Racial differences in the frequency of Q and C chromosomal heteromorphisms

Nature volume 268, pages 631–633 (1977)Cite this article

Abstract

THE biological and clinical implications of human chromosome heteromorphisms are poorly understood. These heteromorphisms are limited to certain groups, and are heritable1. Consistent variability between people, in both size and staining properties, is observed. This may reflect either structural or biochemical variations. Before chromosome banding procedures, the length of the Y was known to vary from person to person and from one ethnic group to another2. Some autosomal regions were also found to differ in various racial groups3,4. Using Q- and C-banding procedures, we have regions scored were (1) on the long arms (qh) of chromosomes 1,9 and 16; (2) on the short arms (P) of the acrocentric autosomes (13–15 and 21–22); and (3) on the centromere (c) of all other chromosomes. The results indicate significant differences between the samples of black and white children.

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Authors and Affiliations

  1. Department of Pediatrics and Department of Biophysics and Genetics, University of Colorado Medical Center, Denver, Colorado, 80220

    H. A. LUBS & W. J. KIMBERLING

  2. Department of Pediatrics, University of Oregon Health Sciences Centre, Portland, Oregon

    F. HECHT & S. R. PATIL

  3. Buffalo Childrens' Hospital, Buffalo, New York

    J. BROWN

  4. also Division of Medical Genetics, Virginia Commonwealth University, Richmond, Virginia

    J. BROWN

  5. Children's Hospital Medical Center, Boston, Massachusetts

    P. GERALD

  6. Department of Pediatrics Genetics Section, University of Tennessee, Memphis, Tennessee

    R. L. SUMMITT

Authors
  1. H. A. LUBS
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  2. W. J. KIMBERLING
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  3. F. HECHT
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  4. S. R. PATIL
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  5. J. BROWN
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  6. P. GERALD
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  7. R. L. SUMMITT
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LUBS, H., KIMBERLING, W., HECHT, F. et al. Racial differences in the frequency of Q and C chromosomal heteromorphisms. Nature 268, 631–633 (1977). https://doi.org/10.1038/268631a0

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