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β-Sheet topology and the relatedness of proteins

Abstract

The topological connectivities of β-pleated sheets in the known protein structures are systematically surveyed for regularly occurring features. The many empirical restrictions found and the distribution of actually occurring topologies among the hypothetically possible ones suggest that striking topological similarities between different proteins can readily happen by chance.

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Richardson, J. β-Sheet topology and the relatedness of proteins. Nature 268, 495–500 (1977). https://doi.org/10.1038/268495a0

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