Abstract
The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29) and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable similarity in other portions of their polypeptide chains. Thus the genes for their proteins may have evolved by duplication of a common ancestral gene. Another lymphocyte cell surface protein of MW 16,000 (p16) has also been characterised. Both p16 and p44 (the heavy chain of HLA–A,B antigens) have been compared with p29 and p34.
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Springer, T., Kaufman, J., Terhorst, C. et al. Purification and structural characterisation of human HLA-linked B-cell antigens. Nature 268, 213–218 (1977). https://doi.org/10.1038/268213a0
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DOI: https://doi.org/10.1038/268213a0
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