Abstract
WE have recorded asymmetrical displacement currents which may be linked to the activation of calcium permeability in the membrane of isolated snail neurones. The search for these currents was prompted by two lines of evidence. First, the existence of ‘gating current’ associated with sodium channel activity1. And second, the existence of voltage-dependent charge movement in muscle fibres, which has some role in excitation–contraction coupling2 and is supposedly involved in the process of calcium release3. An attempt to measure both Ca and Na gating currents in Aplysia neurones has been reported4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Armstrong, C. M. & Bezanilla, F. Nature 242, 459–461 (1973).
Schneider, M. F. & Chandler, W. K. Nature 242, 244–246 (1973).
Chandler, W. K., Rakowski, R. F. & Schneider, M. F. J. Physiol. Lond. 254, 285–316 (1976).
Adams, D. J. & Gage, P. W. Science 192, 783–784 (1976).
Kostyuk, P. G., Krishtal, O. A. & Tsyndrenko, A. J. Neurophysiology (Kiev) 8, 183–191 (1976).
Kostyuk, P. G., Krishtal, O. A. & Pidoplichko, V. I. Nature 257, 691–693 (1975).
Katz, G. M. & Schwartz, T. L. J. Membrane Biol. 17, 275–291 (1974).
Keynes, R. D., Rojas, E., Taylor, R. E. & Vergara, J. J. Physiol. Lond. 229, 409–455 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KOSTYUK, P., KRISHTAL, O. & PIDOPLICHKO, V. Asymmetrical displacement currents in nerve cell membrane and effect of internal fluoride. Nature 267, 70–72 (1977). https://doi.org/10.1038/267070a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/267070a0
This article is cited by
-
Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?
Skeletal Muscle (2018)
-
Moderate Hypoxia Influences Excitability and Blocks Dendrotoxin Sensitive K+ Currents in Rat Primary Sensory Neurones
Molecular Pain (2006)
-
From Galvani to patch clamp: the development of electrophysiology
Pflügers Archiv - European Journal of Physiology (2006)
-
Calcium channels in the cell membrane
Neuroscience and Behavioral Physiology (1986)
-
Slow asymmetric currents and tubulo-reticular junction ultrastructure in crayfish muscle fibers
Neurophysiology (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
