Article | Published:

Defective interfering particles with covalently linked [±]RNA induce interferon

Naturevolume 266pages815819 (1977) | Download Citation

Subjects

Abstract

Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [−]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [−]RNA DI particles with the same polypeptide composition as [±]RNA DI particles fail to induce interferon.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Lazzarini, R. A., Weber, G. H., Johnson, L. D. & Stamminger, G. M. J. molec. Biol. 97, 289–307 (1975).

  2. 2

    Huang, A. S. & Baltimore, D. Nature 226, 325–327 (1970).

  3. 3

    Marcus, P. I. & Sekellick, M. J. Virology 57, 321–338 (1974).

  4. 4

    Marcus, P. I. & Sekellick, M. J. Virology 63, 176–190 (1975).

  5. 5

    Burke, D. C. Interferons and Interferon Inducers (ed. Finter, N. B.), 108 (North-Holland, Amsterdam & London, 1973).

  6. 6

    Carver, D. H. & Marcus, P. I. Virology 32, 247–257 (1967).

  7. 7

    Carter, W. A. & De Clercq, E. Science 186, 1172–1178 (1974).

  8. 8

    Bellett, A. J. D. & Cooper, P. D. J. gen. Microbiol. 21, 498–509 (1959).

  9. 9

    Previc, L., & Kang, C. Y. Nature 228, 25–27 (1970).

  10. 10

    Luria, S. E. Ann Inst. Pasteur 64, 415–436 (1940).

  11. 11

    De Clercq, E. & Merigan, T. C. Nature 222, 1148–1152 (1969).

  12. 12

    Glasgow, L. A. Infect. Immun. 9, 702–707 (1974).

  13. 13

    Vilček, J. & Havell, E. A. Proc. natn. Acad. Sci. U.S.A. 70, 3909–3913 (1973).

  14. 14

    Desmyter, J., Melnick, J. L. & Rawls, W. E. J. Virol. 2, 955–961 (1968).

  15. 15

    Marcus, P. I. & Sekellick, M. J. Virology 69, 378–393 (1976).

  16. 16

    Marcus, P. I. & Puck, T. T. Virology 6, 405–423 (1958).

  17. 17

    Holland, J. J. & Villarreal, L. P. Proc. natn. Acad. Sci. U.S.A. 71, 2956–2960 (1974).

  18. 18

    Wagner, R. R., Schnaitman, T. C. & Snyder, R. M. J. Virol 3, 395–403 (1969).

  19. 19

    Greene, J., Alderfer, J., Ts'o, P., O'Malley, J. & Carter, W. Am. Soc. Microbiol. Abstr., 252 (1976).

  20. 20

    Falcoff, R., Falcoff, E. & Catinot, L. Biochim. biophys. Acta 217, 195–198 (1970).

  21. 21

    Friedman, R. M. & Costa, J. R. Infect. Immun. 13, 487–493 (1976).

  22. 22

    Youngner, J. S. & Wertz, G. J. Virol. 2, 1360–1361 (1968).

  23. 23

    Sodja, I. Acta Virol. (Praha) 19, 84–87 (1975).

  24. 24

    Nozaki, J. & Atanasiu, P. Ann. Microbiol. (Inst. Pasteur) 126 B, 381–388 (1975).

  25. 25

    Perrault, J. Virology 70, 360–371 (1976).

  26. 26

    Hunt, T. & Ehrenfeld, E. Nature new Biol. 230, 91–94 (1971).

  27. 27

    Cordell-Stewart, B. & Taylor, M. W. J. Virol. 12, 360–366 (1973).

  28. 28

    Marcus, P. I. & Carver, D. H. Science 149, 983–986 (1965).

Download references

Author information

Affiliations

  1. Microbiology Section, U-44, University of Connecticut, Storrs, Connecticut, 06268

    • Philip I. Marcus
    •  & Margaret J. Sekellick

Authors

  1. Search for Philip I. Marcus in:

  2. Search for Margaret J. Sekellick in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266815a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.