Letter | Published:

Inhibition by sera and soluble antigens of T-cell-mediated cytotoxicity against leukaemia-associated antigens

Naturevolume 266pages727729 (1977) | Download Citation

Subjects

Abstract

INTEREST in the regulation of T-cell-mediated cytotoxicity by the major histocompatibility complex (MHC) genes stems from the discovery of (1) an H–2 restriction of T-cell-mediated cytotoxicity, that is sensitising cells, effector cells and target cells need to be syngeneic at the H–2 locus, especially at the D and or K regions of the MHC1–5 for effective killing and (2) inhibition of T-cell-mediated cytotoxic reactions against syngeneic tumours with alloantibodies to H–2 antigens specific for the tumour cells6,7. Different origins have been proposed for the tumour-associated antigens (TAA), and the most favourable model is a modified H–2 antigen or an adaptor–antigen complex4–7. This issue has important implications for tumour immunology, and so we have evaluated the validity of the inhibition of cytotoxicity by serum at the effector phase level; investigated afferent interference by serum of the cell-mediated cytotoxic response, and studied the inhibition of cell-mediated cytotoxic reactions with soluble antigens. We report here that there is a lack of H–2 restriction of T-cell-mediated cytotoxicity to TAA, and that TAA seems to differ from H–2 antigens. This implies that T-cell recognition is not entirely regulated by the MHC genes.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

  2. 2

    Blanden, R. Y. et al. Nature 254, 269–270 (1975).

  3. 3

    Koszinowski, U. & Thomssen, R. Eur. J. Immun. 5, 245–251 (1975).

  4. 4

    Gomard, E., Duprez, V., Henin, Y. & Levy, J. P. Nature 260, 707–709 (1976).

  5. 5

    Blank, K. J., Freedman, H. A. & Lilly, F. Nature 260, 250–252 (1976).

  6. 6

    Germain, R. N., Dorf, M. E. & Benacerraf, B. J. exp. Med. 142, 1023–1028 (1975).

  7. 7

    Schrader, J. W., Cunningham, B. A. & Edelman, G. M. Proc. natn. Acad. Sci U.S.A. 72, 5066–5070 (1975).

  8. 8

    Ting, C. C., Bushar, G. S., Rodrigues, D. & Herberman, R. B. J. Immun. 115, 1351–1356 (1975).

  9. 9

    Glynn, J. P., McCoy, J. L. & Fefer, A. Cancer Res. 28, 434–439 (1968).

  10. 10

    Ting, C. C. & Bonnard, G. D. J. Immun. 116, 1419–1425 (1976).

  11. 11

    Ting, C. C., Rodrigues, D., Busbar, G. S. & Herberman, R. B. J. Immun. 116, 236–243 (1976).

  12. 12

    Ting, C. C., Kirchner, H., Rodrigues, D., Park, J. Y. & Herberman, R. B. J. Immun. 116, 244–252 (1976).

  13. 13

    Freedman, H. A. & Lilly, F. J. exp. Med. 142, 212–223 (1975).

  14. 14

    Ting, C. C. & Law, L. W. J. Immun. (in the press).

  15. 15

    Sparks, F. C., Ting, C. C., Hammond, W. G. & Herberman, R. B. J. Immun. 102, 842–847 (1969).

  16. 16

    Ting, C. C. & Herberman, R. B. Nature 257, 801–802 (1975).

  17. 17

    Trinchieri, G., Aden, D. P. & Knowles, B. B. Nature 261, 312–314 (1976).

Download references

Author information

Affiliations

  1. Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    • CHOU-CHIK TING
    •  & MICHAEL J. ROGERS

Authors

  1. Search for CHOU-CHIK TING in:

  2. Search for MICHAEL J. ROGERS in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266727a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.