Letter | Published:

Evidence for control of complement receptor rosette-forming cells by α- and β-adrenergic agents

Naturevolume 266pages633635 (1977) | Download Citation

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Abstract

PHARMACOLOGICAL agents such as dibutyryl cyclic AMP1,2, cholera toxin3,4 and β-adrenergic stimulants5 have an effect on antibody production which can be inhibitory or enhancing, depending on the dose used and the time of addition of the agent. Such stimulants are known to inhibit the human T-lymphocyte receptor for sheep erythrocytes6,7 and the murine lymphoma Fc receptor8, and it has been shown that the complement receptor on B lymphocytes has an important role in the cellular events leading to antibody production9,10, thus emphasising the need to clarify its nature. We report here that the number of complement receptor rosette-forming cells (EAC–RFC) in suspensions of mouse spleen cells can be decreased by α-adrenergic stimulants and increased by β-adrenergic stimulants, respectively.

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Author information

Author notes

    • MASAHIKO ITO

    Present address: Fukushima Medical College, Fukushima, Sugizuma-cho, 5-75, Japan

Affiliations

  1. Department of Bacteriology and Immunology, University of Glasgow, Western Infirmary, Glasgow, UK

    • MASAHIKO ITO
    • , FREDERICK SLESS
    •  & DELPHINE M. V. PARROTT

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https://doi.org/10.1038/266633a0

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