Letter | Published:

Enkephalin may mediate euphoria and drive-reduction reward

Naturevolume 266pages556558 (1977) | Download Citation

Subjects

Abstract

THE identification in brain of opiate receptors1 and morphine-like pentapeptides (methionine-enkephalin and leucine-enkephalin)2 has led to suggestions that enkephalin receptors may be sites at which opiate drugs induce analgesia and euphoria, and that the enkephalins themselves may be transmitters or modulators in brain systems for the regulation of pain and pleasure3–6. Observations in animals reveal that appropriate central administration of enkephalin produces morphine-like analgesia7–9 and physical dependence10. We report here that enkephalin also may share the euphorigenic or rewarding properties of morphine in that rats will work for enkephalin injections delivered directly into the ventricles of their own brains11. Of particular interest, in the light of the generally superior potency of the methionine peptide2,8,9, is the observation that leucine-enkephalin is self-administered with greater avidity than methionine-enkephalin.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Goldstein, A. Science 193, 1081–1086 (1976).

  2. 2

    Hughes, J. et al. Nature 258, 577–579 (1975).

  3. 3

    Kosterlitz, H. W. & Hughes, J. Life Sci. 17, 91–96 (1975).

  4. 4

    Liebeskind, J. D., Giesler, G. J. & Urca, G. in Sensory Functions of the Skin (ed. Zotterman, Y.) 561–573 (Pergamon, Oxford, 1976).

  5. 5

    Snyder, S. H. Nature 257, 185–189 (1975).

  6. 6

    Byck, R. Lancet ii, 72–73 (1976).

  7. 7

    Belluzzi, J. D. et al. Nature 260, 625–626 (1976).

  8. 8

    Buscher, H. H. et al. Nature 261, 423–425 (1976).

  9. 9

    Chang, J-K., Fong, B. T. N., Pert, A. & Pert, C. Life Sci. 18, 1473–1482 (1976).

  10. 10

    Wei, E. & Loh, H. Sciences 193, 1262 (1976).

  11. 11

    Belluzzi, J. D., Wise, C. D. & Stein, L. Neurosci. Abstr. 2, 564 (1976).

  12. 12

    Amit, Z., Brown, Z. W. & Sklar, L. S. Psychopharmacology 48, 291–294 (1976).

  13. 13

    Simantov, R. & Snyder, S. H. Life Sci. 18, 781–788 (1976).

  14. 14

    German, D. C. & Bowden, D. M. Brain Res. 73, 381 (1974).

  15. 15

    Elde, R., Hökfelt, T., Johansson, O. & Terenius, L. Neuroscience 1, 349–352 (1976).

  16. 16

    Mayer, D. J., Wolfe, T. L., Akil, H., Carder, B. & Liebeskind, J. C. Science 174, 1351–1354 (1971).

  17. 17

    Versteeg, D. H. G., Van DerGugten, J., DeJong, W. & Palkovits, M. Brain Res. 113, 563–574 (1976).

  18. 18

    Stein, L., Belluzzi, J. D. & Wise, C. D. in Brain-Stimulation Reward (eds Wauquire, A. & Rolls, E. T.) 297–331 (North-Holland, Amsterdam, 1976).

  19. 19

    Pozuelo, J. & Kerr, F. W. L. Mayo Clin. Proc. 47, 621–628 (1972).

  20. 20

    Davis, W. M., Smith, S. G. & Khalsa, J. H. Pharmac. Biochem. Behav. 3, 477–484 (1975).

  21. 21

    Crow, T. J. Psychol. Med. 3, 66–73 (1973).

Download references

Author information

Affiliations

  1. Wyeth Laboratories, P.O. Box 8299, Philadelphia, Pennsylvania, 19101

    • JAMES D. BELLUZZI
    •  & LARRY STEIN

Authors

  1. Search for JAMES D. BELLUZZI in:

  2. Search for LARRY STEIN in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/266556a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.