Effects of immunisation against luteinising hormone releasing hormone on reproduction of the marmoset monkey Callithrix jacchus

Abstract

LUTEINISING hormone releasing hormone (LHRH) is a decapeptide secreted by the hypothalamus and transported through the hypophysial portal system to the anterior pituitary gland where it acts to stimulate gonadotrophin release1. Selective neutralisation of this releasing factor by specific antibodies has been achieved in rodents2–4, but there has been no report of similar work on primates. Immunisation against hypothalamic releasing hormones is a potentially suitable method for selective control of the secretion of anterior pituitary hormones. In particular, interference with LHRH release might make possible a new approach to contraception. We describe here how antibodies to LHRH were raised in the marmoset, Callithrix jacchus, and outline the subsequent effects on gonadal activity and pituitary function.

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HODGES, J., HEARN, J. Effects of immunisation against luteinising hormone releasing hormone on reproduction of the marmoset monkey Callithrix jacchus. Nature 265, 746–748 (1977). https://doi.org/10.1038/265746b0

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