Abstract
THERE have been reports1,2 of possible deleterious effects on the mental development of children due to maternal histidinaemia, in which a deficiency of the enzyme histidase leads to the exposure of the foetus to abnormally high concentrations of histidine and its imidazole derivatives. This is analagous to the well established case of maternal phenylketonuria3 which can lead to mental retardation in metabolically normal children. There is also a suggested link4 between low maternal concentrations of two enzymes in galactose metabolism and infantile cataracts. We report here work on the nature of the maternal effects of histidinaemia using mutant mice which are the homologues of the human condition5–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lyon, I. C. T., Gardner, R. J. M., and Veale, A. M. O., Arch. Dis. Child., 49, 581 (1974).
Harper, P. S., Heredity, 34, 289 (1975).
Denniston, J. C., J. Pediat., 63, 461 (1963).
Harley, J. D., Mutton, P., Irvine, S., and Gupta, J. A., Lancet, ii, 259 (1974).
Kacser, H., Bulfield, G., and Wallace, M. E., Nature, 244, 77 (1973).
Bulfield, G., and Kacser, H., Arch. Dis. Child., 49, 545 (1974).
Bulfield, G., and Kacser, H., J. Neurochem., 24, 403 (1975).
Rugh, R., Radiology, 82, 917 (1964).
Blake, R. L., and Russell, E. S., Science, 176, 809 (1972).
Blake, R. L., Biochem. J., 129, 987 (1972).
Blake, R. L., and Russell, E. S., Genetics, 74, 526 (1973).
McLaren, A., and Michie, D., J. exp. Biol., 33, 394 (1956).
Wallace, M. E., Mouse Newslett., 42, 20 (1970).
Wallace, M. E., Mouse Newslett., 48, 25 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KACSER, H., MYA MYA, K., DUNCKER, M. et al. Maternal histidine metabolism and its effect on foetal development in the mouse. Nature 265, 262–266 (1977). https://doi.org/10.1038/265262a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/265262a0
This article is cited by
-
Differential regulation of two histidine ammonia-lyase genes during Xenopus development implicates distinct functions during thyroid hormone-induced formation of adult stem cells
Cell & Bioscience (2013)
-
Histidinaemia. Part II: Impact; a retrospective study
Journal of Inherited Metabolic Disease (1983)
-
Comparison of the properties of histidine ammonia-lyase in normal and histidinemic mutant mice
Biochemical Genetics (1982)
-
Inherited metabolic disease in laboratory animals: a review
Journal of Inherited Metabolic Disease (1980)
-
Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: A structural locus for a cytosol histidine aminotransferase isozyme (Hat-1)
Biochemical Genetics (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.