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Lymphocytes with T-cell markers cooperate with IgG antibodies in the lysis of human tumour cells

Nature volume 265, pages 158–160 (1977)Cite this article

Abstract

THYMUS-DERIVED (T) lymphocytes from animals immunised with syngeneic or allogeneic tumour cells are well known to kill specifically target cells in vitro1. The as yet unidentified antigen recognition structure on T lymphocytes is not deemed to be a conventional type of immunoglobulin. In contrast to this kind of cell-mediated cytolysis another cellular killing mechanism has been described, called antibody-dependent cell-mediated cytolysis (ADCC), in which cells bearing the Fc receptor (FcR) cooperate with humoral antibody in the cytolytic action2,3. The nature of the main lymphoid effector cells (K cells) involved in the latter system is still ill-defined. They are supposed not to be T lymphocytes. Recently however, Lamon et al. reported on mouse thymocytes which were able to lyse MSV-induced tumour cells using IgM antibodies4. In this report we present evidence that human lymphocytes bearing the T marker in collaboration with homologous or autologous antibodies can efficiently kill tumour cells in vitro.

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Authors and Affiliations

  1. Abt.f. Experimentelle Chirurgie und Immunologie, Chirurgische Universitätsklinik, Calwer Strasse 7, D-7400, Tübingen, West Germany

    J. G. SAAL, E. P. RIEBER, M. HADAM & G. RIETHMULLER

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  1. J. G. SAAL
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  2. E. P. RIEBER
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  3. M. HADAM
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  4. G. RIETHMULLER
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SAAL, J., RIEBER, E., HADAM, M. et al. Lymphocytes with T-cell markers cooperate with IgG antibodies in the lysis of human tumour cells. Nature 265, 158–160 (1977). https://doi.org/10.1038/265158a0

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