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Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA

Nature volume 264, pages 719–722 (1976)Cite this article

Abstract

Strains of yeast carrying mutations in many of the steps in pathways repairing radiation-induced damage to DNA have enhanced spontaneous mutation rates. Most strains isolated because they have enhanced spontaneous mutation carry mutations in DNA repair systems. This suggests that much spontaneous mutation arises by mutagenic repair of spontaneous lesions.

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Authors and Affiliations

  1. Department of Genetics, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9

    P. J. Hastings, Siew-Keen Quah & R. C. von Borstel

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  1. P. J. Hastings
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  2. Siew-Keen Quah
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  3. R. C. von Borstel
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Hastings, P., Quah, SK. & von Borstel, R. Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA. Nature 264, 719–722 (1976). https://doi.org/10.1038/264719a0

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