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Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat

Nature volume 264, pages 83–84 (1976)Cite this article

Abstract

EVIDENCE is accumulating that substance P (H–Arg–Pro–Lys–Pro–Gln–Gln–Phe–Phe–Gly–Leu–Met–NH2)1 is an excitatory transmitter released from primary afferent nerve terminals in mammalian spinal cord (for reviews see refs 2 and 3). An important criterion for identification of a transmitter is the demonstration of release of the candidate substance from the nerve terminals in response to presynaptic stimulation. We report here the release of substance P-like immunoreactivity from isolated rat spinal cord into the bathing fluid during stimulation of dorsal roots.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

    MASANORI OTSUKA & SHIRO KONISHI

Authors
  1. MASANORI OTSUKA
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  2. SHIRO KONISHI
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OTSUKA, M., KONISHI, S. Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat. Nature 264, 83–84 (1976). https://doi.org/10.1038/264083a0

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  • DOI: https://doi.org/10.1038/264083a0

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