Growth of transplanted monoaminergic neurones into the adult hippocampus along the perforant path

Abstract

CENTRAL and peripheral monoaminergic neurones have been found to survive transplantation to certain sites in the adult rat brain1. The neurones grow extensively in their new location and the newly formed axons extend through the surrounding scar tissue into the host brain. We now report experiments in which transplants of adrenergic, dopaminergic or indolaminergic neurones were transplanted to a cavity in the retrosplenial cortex to give them the opportunity to grow along the lesioned temporoammonic perforant path into the partly denervated hippocampal formation. The results demonstrate a remarkable ability of the regenerating axons to establish reproducible and characteristic terminal patterns in large areas of the hippocampus.

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