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Cellular basis for the T wave of the electrocardiogram

Nature volume 262, pages 657–661 (1976)Cite this article

Abstract

Differences in action potential duration in different regions of the mammalian ventricle are not systematically present when quiescent tissue is first stimulated, but develop rapidly during repetitive activity. The effects of ouabain and temperature suggest the involvement of the Na+–K+ exchange pump.

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References

  1. Burgess, M. J., Green, L. S., Millar, K., Wyatt, R., and Abildskov, J. A., Am. Heart J., 84, 660–669 (1972).

    Article  CAS  Google Scholar 

  2. Spach, M. S., and Barr, R. C., Circulation Res., 37, 243–257 (1975).

    Article  CAS  Google Scholar 

  3. Mines, G. R., J. Physiol., Lond., 46, 188–235 (1913).

    Article  CAS  Google Scholar 

  4. Solbery, L. E., Singer, D. H., Ten Eick, R. E., and Duffin, E. G., Circulation Res., 30, 783–797 (1974).

    Article  Google Scholar 

  5. Noble, D., and Tsien, R. W., in Electrical Phenomena in the Heart (edit. by de Mello, W. F.), 133–161 (Academic, New York, 1972).

    Book  Google Scholar 

  6. Hauswirth, O., Noble, D., and Tsien, R. W., J. Physiol., Lond., 222, 27–51 (1972).

    Article  Google Scholar 

  7. Cohen, I., Daut, J., and Noble, D., J. Physiol., Lond. (in the press).

  8. Mobley, B. A., and Page, E., J. Physiol., Lond., 220, 547–563 (1972).

    Article  CAS  Google Scholar 

  9. Page, S., and Niedergerke, R., J. cell. Sci., 11, 179–203 (1972).

    CAS  PubMed  Google Scholar 

  10. Hellam, D. C., and Studt, J. W., J. Physiol., Lond., 243, 637–660 (1974).

    Article  CAS  Google Scholar 

  11. Noble, S. J., J. Physiol., Lond. (in the press).

  12. Cohen, I., Daut, J., and Noble, D., J. Physiol., Lond. (in the press).

  13. Weidmann, S., J. Physiol., Lond., 132, 157–163 (1956).

    Article  CAS  Google Scholar 

  14. Noble, D., J. cell. comp. Physiol., 66, Suppl. 2, 127–136 (1965).

    Article  Google Scholar 

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Authors and Affiliations

  1. University Laboratory of Physiology, South Parks Road, Oxford, UK

    I. Cohen, W. Giles & D. Noble

Authors
  1. I. Cohen
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  2. W. Giles
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  3. D. Noble
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Cohen, I., Giles, W. & Noble, D. Cellular basis for the T wave of the electrocardiogram. Nature 262, 657–661 (1976). https://doi.org/10.1038/262657a0

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