Abstract
CURRENT interest in polypeptides as neurotransmitter substances in the central nervous system (CNS) has been focused on their ability to depolarise motoneurones1 and to excite single cells in various parts of the brain2–6. An additional feature of their actions on nervous tissue, however, is the development of ‘tachyphylaxis’ or ‘desensitisation’ to their effects during repeated administration. This phenomenon has been reported with two structurally related undecapeptides in particular, substance P and eledoisin, both in spinal cord7 and in brain3–5. We report here that in the substantia nigra additional changes in amino acid sensitivity occur during such a period of desensitisation to eledoisin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Otsuka, M., Konishi, S., and Takahashi, T., Fedn Proc., 34, 1922–1928 (1975).
Krnjevic, K., and Morris, M. E., Can. J. Physiol. Pharmac., 52, 736–744 (1974).
Phillis, J. W., and Limacher, J. J., Brain Res., 69, 158–163 (1974).
Henry, J. L., Krnjevic, K., and Morris, M. E., Can. J. Physiol. Pharmac., 53, 423–432 (1975).
Davies, J., and Dray, A., Brain Res., 107, 623–627 (1976).
Walker, R. J., Kemp, J. A., Yajima, H., Kitagawa, K., and Woodruff, G. N., Experientia, 32, 214–215 (1976).
Evans, R. H., Francis, A. A., and Watkins, J. C., Br. J. Pharmac. (in the press).
Dray, A., Gonye, T. J., and Oakley, N. R., J. Physiol., Lond. (in the press).
Dray, A., and Straughan, D. W., J. Pharm. Pharmac., Suppl., 28, 400–405 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIES, J., DRAY, A. Changes in amino acid sensitivity during polypeptide ‘desensitisation’. Nature 262, 606–607 (1976). https://doi.org/10.1038/262606a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/262606a0
This article is cited by
-
Taurine infused intrastriatally elevates, but intranigrally decreases striatal extracellular dopamine concentration in anaesthetised rats
Journal of Neural Transmission (1996)
-
High-sensitivity radioimmunoassay for substance P
Irish Journal of Medical Science (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.