Spleen cells from Schistosoma mansoni-infected mice produce diffusible stimulator of eosinophilopoiesis in vivo


WE have previously demonstrated that a diffusible stimulator of eosinophilopoiesis is produced in mice after secondary injection with tetanus toxoid (TT)1. Lymphoid cells from TT-primed animals are capable of producing a diffusible eosinophilopoietic stimulator in non-primed hosts on intraperitoneal TT injection2. To establish that this is not a unique phenomenon, limited to this antigen, but rather that it is characteristic of antigen-induced eosinophilias and associated eosinophilopoietic responses, we have studied eosinophilopoiesis in a parasite-induced eosinophilia.

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