Abstract
SERUM proteins1,2 like intracellular proteins3–7, are continually being degraded and replaced at characteristic rates. Although there is appreciable evidence that structural alterations can influence the half lives of serum proteins8–11, the features of serum proteins which normally influence their degradative rates are unknown. The present experiments were undertaken to learn more about the factors influencing the degradation of serum proteins and to explore any possible relationship of this process to the catabolism of intracellular proteins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schreier, K., and Porath, U., in Physiology and Pathophysiology of Plasma Protein Metabolism (edit. by Koblet, H., et al.), 122–134 (Grune and Stratton, New York, 1966).
McFarland, A. S., (ed.), Protein Turnover Ciba Foundation Symposium 9 (North Holland, Amsterdam, 1973).
Schimke, R. T., Mammalian Protein Metabolism, 4 (edit. by Munro, H. N.) 178–228 (1970).
Rechcigl, M., in Enzyme Synthesis and Degradation in Mammalian Systems (edit. by Rechcigl, M.), 237–311 (University Park Press, Baltimore, 1971).
Goldberg, A. L., and Dice, J. F., A. Rev. Biochem., 43, 835–869 (1974).
Goldberg, A. L., and St John, A., A. Rev. Biochem., 45 (in the press).
Dice, J. F., Dehlinger, P. J., and Schimke, R. T., J. biol. Chem., 248, 4220–4228 (1973).
Mego, J. L., and McQueen, J. D., Biochim. Biophys. Acta, 100, 136–143 (1965).
Kirsch, R. E., Frith, L. O., and Saunders, S. J., Biochim. biophys. Acta, 279, 87–91 (1972).
Morell, A. G., Gregoriadis, G., and Scheinberg, I. H., J. biol. Chem., 246, 1461–1467 (1971).
Ashwell, G., and Morell, A. G., Adv. Enzymol., 41, 99–128 (1974).
Segal, H. L., Winkler, J. R., and Miyagi, M. P., J. biol. Chem., 249, 6364–6365 (1974).
Dean, R. T., Eur. J. Biochem., 58, 9–14 (1975).
Bohley, P., Langner, J., Ansorge, S., Miehe, M., Miehe, C., and Hanson, H., Acta biol. med. Ger., 28, 321–328 (1972).
Dice, J. F., and Goldberg, A. L., Archs. biochem. Biophys., 170, 213–219 (1975).
Dice, J. F., and Goldberg, A. L., Proc. natn. Acad. Sci. U.S.A., 72, 3893–3897 (1975).
Arias, I. M., Doyle, D., and Schimke, R. T., J. biol. Chem., 244, 3303–3315 (1969).
Poole, B., J. biol. Chem., 246, 6587–6591 (1971).
Bretscher, M. S., Nature new Biol., 231, 229–232 (1971).
Segrest, J. P., Jackson, R. L., Andrews, E. P., and Marchesi, V. T., Biochem. biophys. Res. Commun., 44, 390–395 (1971).
Dehlinger, P. J., and Schimke, R. T., Biochem. biophys. Res. Commun., 40, 1473–1480 (1970).
Pappenheimer, J. F., Phys. Rev., 33, 387–423 (1953).
Davidson, S. J., J. Cell Biol., 59, 213–222 (1973).
Creemers, J., and Jacques, P. J., Expl Cell Res., 67, 188–203 (1971).
Williams, K. E., Lloyd, J. B., Davies, M., and Beck, F., Biochem. J., 125, 303–308 (1971).
Williams, K. E., Kidston, E. M., Beck, F., and Lloyd, J. B., J. Cell Biol., 64, 123–134 (1975).
Gordon, A. H., and Jacques, P. J., in Labelled Proteins in Tracer Studies (edit. by Donato, L., Milhaud, G., and Sirchis, J.), 127–133 (Euratom, 1966).
Jacques, P. J., in Pathologic Aspects of Cellular Membranes (edit. by Trump, B. J., and Arstila, A.) (Academic, New York, 1974).
Wild, A. E., in Biology and Pathology, 3 (edit. by Dingle, J. T.), 169–215 (North Holland, Amsterdam, 1973).
Buys, C. H. C. M., Elferink, M. G. L., Bouma, J. M. W., Guber, M., and Nieuwenhuis, P., J. Reticutoendothel. Soc., 14, 209–223 (1973).
Penn, N. W., Biochim. biophys. Acta, 37, 55–61 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DICE, J., GOLDBERG, A. Structural properties of rat serum proteins which correlate with their degradative rates in vivo. Nature 262, 514–516 (1976). https://doi.org/10.1038/262514a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/262514a0
This article is cited by
-
Quality control of protein folding in extracellular space
EMBO reports (2005)
-
Protein synthesis rates in rat brain regions and subcellular fractions during aging
Neurochemical Research (1988)
-
The breakdown of the individual neurofilament proteins by cathepsin D
Neurochemical Research (1987)
-
Amino acid incorporation in relation to molecular weight of proteins in young and adult brain
Neurochemical Research (1986)
-
Asialoprotein uptake by liver cells: Immunofluorescence microscopy
Experientia (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
