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Further evidence for derepression of H–2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines

Nature volume 261, pages 705–707 (1976)Cite this article

Abstract

WE reported earlier the appearance of specificities like those of foreign H–2 haplotypes on a mouse sarcoma after vaccinia virus infection1. The presence of these foreign transplantation antigens was apparently sufficient to inhibit the growth of the tumour (unpublished data). Parallel work in man has shown qualitative changes in the HLA profile of fibroblasts grown in tissue culture and infected with SV40 virus2. The mechanism by which a virus can induce changes in the pattern of cell surface histocompatibility antigens remains obscure.

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Authors and Affiliations

  1. Tissue Immunology Unit, The London Hospital Medical College, Turner Street, London, E1 2AD, UK

    FEDERICO GARRIDO & HILLIARD FESTENSTEIN

  2. Institute of Immunology and Genetics, Department of Cellular Immunology, Deutsches Krebsforschungszentrum, Heidelberg, FRG

    VOLKER SCHIRRMACHER

Authors
  1. FEDERICO GARRIDO
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  2. HILLIARD FESTENSTEIN
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  3. VOLKER SCHIRRMACHER
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GARRIDO, F., FESTENSTEIN, H. & SCHIRRMACHER, V. Further evidence for derepression of H–2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines. Nature 261, 705–707 (1976). https://doi.org/10.1038/261705a0

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