Abstract
THE therapeutic usefulness of many anti-cancer agents depends on their selective toxicity for cells in the S (DNA synthesising) phase of the cell cycle1. Thus, rapidly proliferating cancer cells are more effectively killed by these agents than are normal cell populations, which have a lower proportion of cells in S. In theory, it should be possible to reduce the toxicity of such agents significantly by further slowing the entry of normal cells into S. We have tested this possibility in vitro by exploiting the ability of cyclic AMP derivatives to inhibit the entry into S phase of 3T3 cells, but not their malignant counterparts, transformed by SV40.
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ROZENGURT, E., Po, C. Selective cytotoxicity for transformed 3T3 cells. Nature 261, 701–702 (1976). https://doi.org/10.1038/261701a0
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DOI: https://doi.org/10.1038/261701a0
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