Abstract
THE mechanism of prophage induction by radiation or chemical agents is unknown, although during the past decade a variety of hypotheses have been advanced1–6. Sussman and Ben Zeev7 have presented biochemical data that seem to favour the suggestion that DNA intermediates in repair of DNA damage are competitors with the prophage operators for represser binding. When sufficient represser is bound to these regions none remains for prophage repression and so induction follows7. A consequence of this hypothesis is the prediction that induction should not occur in the absence of these normal repair processes. Here we test and verify this prediction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tomizawa, J., and Ogawa, T. J. molec. Biol., 23, 247–263 (1967).
Witkin, E. M., Proc. natn. Acad. Sci. U.S.A., 57, 1275–1279 (1967).
Goldthwait, D., and Jacob, F., C. r. hebd. Séanc. Acad. Sci. Paris, 259, 661–664 (1969).
Devoret, R., and Blanko, M., Molec. gen. Genet., 107, 272–280 (1970).
Castellazzi, M., George, J., and Buttin, G., Molec. gen. Genet., 119, 153–174. (1972).
Radman, M., in Molecular and Environmental Aspects of Mutagenesis (edit. by Prakash, I., et al.), 128–142 (Thomas, Springfield, Illinois, 1974).
Sussman, R., and Ben Zeev, H. Proc. natn. Acad. Sci. U.S.A., 72, 1973–1976 (1975).
Howard-Flanders, P., Boyce, R. P., and Theriot, L., Genetics, 53, 1119–1136 (1966).
Rupp, W. D., and Howard-Flanders, P., J. molec. Biol., 31, 291–304 (1968).
Iyer, V. N., and Rupp, W. D., Biochim. biophys. Acta, 228, 117–126 (1971).
Abe, M., and Tomizawa, J. Genetics, 69, 1–15 (1971).
Monk, M., and Gross, J., Molec. gen. Genet., 110, 299–306 (1971).
Miller, J. H., Experiments in Molecular Genetics, 431 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRAUN, A. Host DNA replication or excision repair requirement for ultraviolet induction of bacteriophage λ lysogens. Nature 261, 164–166 (1976). https://doi.org/10.1038/261164a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/261164a0
This article is cited by
-
Influence of superinfection on the photoreversible phase of UV induced lysogenic bacteria
Molecular and General Genetics MGG (1981)
-
Expression of λ red genes restores recB-dependent protein X induction in E. coli
Nature (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.