Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Transport of globin mRNA from nucleus into cytoplasm in differentiating embryonic red blood cells

Nature volume 261, pages 157–159 (1976)Cite this article

Abstract

ERYTHROPOIESIS in chick embryos provides a useful experimental system to study specific gene regulation during embryonic differentiation. As they mature, red blood cells become almost totally committed to the synthesis of one set of gene products—haemoglobin peptide chains. Thus, the transcriptional and post-transcriptional processes involved in the expression of the globin genes can be conveniently studied in erythroid cells undergoing maturation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bruns, G. A. P., and Ingram, V. M., Phil. Trans. R. Soc. B 266, 225–305 (1973).

    Article  CAS  Google Scholar 

  2. Chan, L.-N. L., and Ingram, V. M., J. Cell. Biol., 56, 861–865 (1973).

    Article  CAS  Google Scholar 

  3. Chan, L.-N. L., Wiedmann, M., and Ingram, V. M., Devl. Biol., 40, 174–185 (Butterworths, London, 1974).

    Article  CAS  Google Scholar 

  4. Wilt, F. H., J. molec. Biol., 12, 331–341 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Kafatos, F. C., and Gelinas, R., MTP Int. Rev. Sci. Biochem. Ser., 9, 223–264 (Butterworths, London, 1974).

    CAS  Google Scholar 

  6. Hunt, J. A., Biochem. J., 138, 499–510 (1973).

    Article  Google Scholar 

  7. Gurdon, J. B., Woodland, H. R., and Lingrel, J. B., Devl Biol., 39, 125–133 (1974).

    Article  CAS  Google Scholar 

  8. Ross, J., Ikawa, Y., and Leder, P., Proc. natn. Acad. Sci. U.S.A., 69, 3620–3623 (1972).

    Article  ADS  CAS  Google Scholar 

  9. Weintraub, H., Campbell, G., and Holtzer, H., J. Cell. Biol., 50, 652–668 (1971).

    Article  CAS  Google Scholar 

  10. Hagopian, H. K., Lippke, J. A., and Ingram, V. M., J. Cell. Biol., 54, 98–106 (1972).

    Article  CAS  Google Scholar 

  11. Ingram, V. M., Chan, L.-N. L., Hagopian, H. K., Lippke, J. A., and Wu, L., Devl. Biol., 36, 411–427 (1974).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiology Department, University of Connecticut Health Center, Farmington, Connecticut, 06032

    L.-N. L. CHAN

Authors
  1. L.-N. L. CHAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHAN, LN. Transport of globin mRNA from nucleus into cytoplasm in differentiating embryonic red blood cells. Nature 261, 157–159 (1976). https://doi.org/10.1038/261157a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/261157a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing