Abstract
THE infection of cell cultures with the causative agents of subacute spongiform encephalopathies — scrapie, kuru, Creutzfeldt–Jakob disease and transmissible mink encepha-lopathy—has not yet been reported. The development of a cell line (SMB), from the brain of a mouse affected with scrapie, in which the agent multiplies has shown that replication in vitro is possible1. Studies with this cell line have, however, been limited because no control culture was available for comparative studies. This limitation has now, in part, been overcome by the successful infection of cultures of mouse L cells with scrapie agent, as described here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Clarke, M. C., and Haig, D. A., Res. vet. Sci., 11, 500–501 (1970).
Millson, G. C., Hunter, G. D., and Kimberlin, R. H., in Slow Virus Diseases of Animals and Man (edit. by Kimberlin, R. H.), 243–266 (Elsevier, Amsterdam, 1976).
Poole, A. R., Howell, J. I., and Lucy, J. A., Nature, 227, 810–814 (1970).
Clarke, M. C., and Haig, D. A., Res. vet. Sci., 20, 106–107 (1976).
Clarke, M. C., and Millson, G. C., J. gen. Virol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLARKE, M., MILLSON, G. Infection of a cell line of mouse L fibroblasts with scrapie agent. Nature 261, 144–145 (1976). https://doi.org/10.1038/261144a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/261144a0
This article is cited by
-
Genetically engineered cellular models of prion propagation
Cell and Tissue Research (2023)
-
Attempts to establish the scapie agent in cell lines
Veterinary Research Communications (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
