Abstract
In a discussion of the dynamics of protein folding two limiting models (random-search nucleation and chain propagation., diffusion–collision) are considered. It is suggested that the latter may have the dominant role in many proteins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Anfinson, C. B., and Scheraga, H. A., Adv. Protein Chem., 29, 205–300 (1975).
Baldwin, R. L., A. Rev. Biochem., 44, 453–475 (1975).
Brown, J. E., and Klee, W. A., Biochemistry, 10, 470–476 (1971).
Epand, R. M., J. biol. Chem, 247, 2132–2138 (1972).
Hammes, G. C., and Schullery, S. E., Biochemistry, 7, 3882–3887 (1968).
Gratzer, W. B., and Beaven, G. H., J. biol. Chem., 244, 6675–6679 (1969).
Panijpan, B., and Gratzer, W. B., Eur. J. Biochem., 45, 547–553 (1974).
Sasaki, K., Dockerill, S., Adamiak, D. A., Tickle, I. J., and Blundell, T., Nature, 257, 751–757 (1975).
Ponnuswamy, P. K., Warme, P. K., and Scheraga, H. A., Proc. natn. Acad. Sci. U.S.A., 70, 830–833 (1973).
Wetlaufer, D. B., Proc. natn. Acad. Sci. U.S.A., 70, 697–701 (1973).
Levinthal, C., J. Chim. phys., 65, 44–45 (1968).
Levinthal, C., Scient. Am., 214 (6), 42–52 (1966).
Craig, M. E., Crothers, D. M., and Doty, P. M., J. molec. Biol., 62, 383–401 (1971).
Porschke, D., and Eigen, M., J. molec. Biol., 62, 361–381 (1971).
Schwarz, G., J. molec. Biol., 11, 64–77 (1965).
Schwarz, G., Biopolymers, 6, 873–893 (1968).
Tsong, T. Y., Baldwin, R. L., and McPhie, P., J. molec. Biol., 63, 453–475 (1972).
Tsong, T. Y., Baldwin, R. L., and Elson, E. L., Proc. natn. Acad. Sci. U.S.A., 69, 1809–1812 (1972).
Garel, J.-R., and Baldwin, R. L., Proc. natn. Acad. Sci. U.S.A., 70, 3347–3351 (1973).
Pohl, F. M., Angew. Chem. int. Ed., 11, 894–906 (1972).
Anfinsen, C. B., Science, 181, 223–230 (1973).
Zimm, B. K., and Bragg, J. K., J. chem. Phys., 31, 526–535 (1959).
Sachs, D. H., Schechter, A. N., Eastlake, A., and Anfinsen, C. B., Proc. natn. Acad. Sci. U.S.A., 69, 3790–3794 (1972).
Epstein, H. F., Schechter, A. N., Chen, R. F., and Anfinsen, C. B., J. molec. Biol., 60, 499–508 (1971).
Lewis, P. N., Momany, F. A., and Scheraga, H. A., Proc. natn. Acad. Sci. U.S.A., 68, 2293–2297 (1971).
Crawford, J. L., Lipscomb, W. N., and Schellman, L. G., Proc. natn. Acad. Sci. U.S.A., 70, 538–542 (1973).
Chou, P. Y., and Fasman, G. D., Biochemistry, 13, 222–245 (1974).
Levitt, M., and Warshel, A., Nature, 253, 694–698 (1975).
Gelin, B., and Karplus, M., Proc. natn. Acad. Sci. U.S.A., 72, 2002–2006 (1975).
Nagano, K., J. molec. Biol., 84, 337–372 (1974).
Furie, B., Schechter, A. N., Sachs, D. H., and Anfinsen, C. B., J. molec. Biol., 92, 497–506 (1975).
Light, A., Taniuchi, H., and Chen, R. F., J. biol. Chem., 249, 2285–2293 (1974).
Snell, C. R., and Fasman, G. D., Biochemistry, 12, 1017–1025 (1973).
Ikai, A., and Tanford, C., Nature, 230, 100–102 (1971).
Creighton, T. E., J. molec. Biol., 87, 603–624 (1974).
Ptitsyn, O. B., and Rashin, A. A., Biophys. Chem., 3, 1–20 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Karplus, M., Weaver, D. Protein-folding dynamics. Nature 260, 404–406 (1976). https://doi.org/10.1038/260404a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/260404a0
This article is cited by
-
Mechanisms and pathology of protein misfolding and aggregation
Nature Reviews Molecular Cell Biology (2023)
-
Atomic resolution protein allostery from the multi-state structure of a PDZ domain
Nature Communications (2022)
-
A look back at the molten globule state of proteins: thermodynamic aspects
Biophysical Reviews (2019)
-
Equilibrium folding dynamics of meACP in water, heavy water, and low concentration of urea
Scientific Reports (2017)
-
Specific and intrinsic sequence patterns extracted by deep learning from intra-protein binding and non-binding peptide fragments
Scientific Reports (2017)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.