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Lithium differentially antagonizes self-stimulation facilitated by morphine and (+)-amphetamine

Nature volume 260, pages 161–163 (1976)Cite this article

Abstract

IN spite of widespread use of lithium (Li) in psychiatry, the mechanism underlying its antimanic action is poorly understood. Studies of the effects of Li on spontaneous and drug-induced behavioural activity have yielded conflicting results1–8. Electrical self-stimulation of the brain (SS) may be a promising alternative approach to such studies. This behaviour is believed to be mediated by catecholamines (reviewed in ref. 9), which have also been implicated in the action of Li10–14. Investigations of the effects of Li on SS have been restricted to a small range of doses and to SS in lateral hypothalamus, and the results have not been consistent15,16. We have now used a wider range of doses to investigate the effects of acute and chronic Li on SS in the substantia nigra of rats.

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, 92093

    JEFFREY M. LIEBMAN & DAVID S. SEGAL

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  1. JEFFREY M. LIEBMAN
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  2. DAVID S. SEGAL
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LIEBMAN, J., SEGAL, D. Lithium differentially antagonizes self-stimulation facilitated by morphine and (+)-amphetamine. Nature 260, 161–163 (1976). https://doi.org/10.1038/260161a0

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