Abstract
A protein synthesised during oogenesis seems to be essential for the activation, during blastulation, of the nuclear genes essential for gastrulation and organogenesis. Nuclear transplantation experiments show that this interaction between the protein and the blastula nucleus produces a heritable state of nuclear activation.
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References
Conklin, E. G., Biol. Bull. Woods Hole, 8, 205–230 (1905).
Wilson, E. B., The Cell in Development and Heredity, third ed. (Macmillan, New York, 1925).
Davidson, E. H., Gene Activity in Early Development (Academic, New York, 1968).
Briggs, R., Ann. d'Embryol Morphogen., 1, 105–113 (1969).
Garen, A., and Gehring, W., Proc. natn. Acad. Sci. U.S.A., 69, 2982–2985 (1972).
Okada, M., Kleinman, J. A., and Schneiderman, H. A., Devl Biol., 37, 55–62 (1974).
Whittaker, J. R., Proc. natn. Acad. Sci. U.S.A., 70, 2096–2100 (1973).
Illmensee, K., and Mahowald, A. P., Proc. natn. Acad. Sci. U.S.A., 71, 1016–1020 (1974).
Humphrey, R. R., Devl Biol., 13, 57–76 (1966).
Briggs, R., and Cassens, G., Proc. natn. Acad. Sci. U.S.A., 55, 1103–1109 (1966).
Briggs, R., J. exp. Zool., 181, 271–280 (1972).
Briggs, R., and Justus, J. T., J. exp. Zool., 167, 105–116 (1968).
Malacinski, G. M., and Brothers, A. J., Science, 184, 1142–1147 (1974).
Malacinski, G. M., Devl Biol., 26, 442–451 (1971).
Malacinski, G. M., J. exp. Zool., 181, 409–420 (1972).
Gurdon, J. B., The Control of Gene Expression in Animal Development (Harvard University Press, Cambridge, 1974).
Davidson, E. H., Crippa, M., and Mirsky, A. E., Proc. natn. Acad. Sci. U.S.A., 60, 152–129 (1968).
Carroll, C. R., J. exp. Zool., 187, 409–422 (1974).
Brothers, A. J., in Proc. ICN-UCLA Conf. Devl Biol. (edit. by McMahon, D., and Fox, C. F.), (Benjamin, Reading, in the press).
Briggs, R., Signoret, J., and Humphrey, R. R., Devl Biol., 10, 233–246 (1964).
Harrison, R. G., in A Manual of Experimental Embryology, (edit. by Hamburger, V.), 211–213 (University of Chicago Press, Chicago, 1966).
Arms, K., Devl Biol., 26, 497–502 (1971).
Ignat'eva, G. M., Ontogenez, 6, 626–629 (1972).
Gurdon, J. B., and Brown, D. D., J. molec. Biol., 12, 27–35 (1965).
Ephrussi, B., Hybridization of Somatic Cells (Princeton University Press, Princeton, 1972).
Harris, H., Sidebottom, E., Grace, D. M., and Branwell, M. E., J. Cell Sci., 4, 499–525 (1969).
Gurdon, J. B., and Woodland, H. R., Biol. Rev. Camb. Phil. Soc., 42, 233–267 (1968).
Crippa, M., Nature, 227, 1138–1140 (1970).
Jelinek, W., and Goldstein, L., J. Cell Physiol., 81, 181–196 (1973).
Kroeger, J., Jacob, J. J., and Sirlin, J. L., Expl Cell Res., 31, 416–423 (1963).
Paine, P. L., and Feldherr, C. M., Expl Cell Res., 74, 81–98 (1972).
Arms, K., J. Embryol. exp. Morphol., 20, 367–374 (1968).
Meriam, R. W., J. Cell Sci., 5, 333–349 (1969).
Di Berardino, M. A., and Hoffner, N. J., Expl Cell Res., 94, 235–252 (1975).
Apples, R., Bolund, L., and Ringertz, N. R., J. molec. Biol., 87, 339–355 (1974).
Gurdon, J. B., Nature, 248, 772–776 (1974).
Bonner, W. M., J. Cell Biol., 64, 421–437 (1975).
Hill, R. J., Maundrell, K., and Callan, H. G., J. Cell Sci., 15, 145–161 (1974).
Sommerville, J., and Hill, R. J., Nature new Biol., 245, 104–106 (1973).
Benbow, R. M., and Ford, C. C., Proc. natn. Acad. Sci. U.S.A., 72, 2437–2441 (1975).
Barrett, R., Maryanka, D., Hamlyn, P. H., and Gould, H. J., Proc. natn. Acad. Sci. U.S.A., 71, 5057–5061 (1974).
Maniatis, R., Ptashne, M., and Maurer, R., Nature, 250, 394–397 (1974).
Davidson, E. H., and Britten, R. J., Q. Rev. Biol., 48, 565–612 (1973).
Sonneborn, T. M., Carylogia, 6, suppl., 307–325 (1954).
Hadorn, E., Devl Biol., 13, 424–509 (1966).
Coon, H. G., Proc. natn. Acad. Sci. U.S.A., 55, 66–73 (1966).
Steinberg, M., Yb., Carnegie Instn Wash., 56, 347 (1957).
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Brothers, A. Stable nuclear activation dependent on a protein synthesised during oogenesis. Nature 260, 112–115 (1976). https://doi.org/10.1038/260112a0
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DOI: https://doi.org/10.1038/260112a0
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