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Two kinds of cholinoreceptors on the membrane of the completely isolated identified Planorbarius corneus neurone

Nature volume 259, pages 681–684 (1976)Cite this article

Abstract

WE have found that an identified neurone of the Planorbarius corneus left pedal ganglion (LPed-2 neurone, Fig. 1) responds with depolarisation to nicotinomimetics and with hyper-polarisation to some muscarinomimetics. The LPed-2 neurone of P. corneus contains dopamine1 and is the dopaminergic interneurone sending depolarising and hyperpolarising impulses to some neurones of the visceral and the left parietal ganglion2. Acetycholine (ACh) alone produces depolarisation like a nicotinomimetic; in the presence of tubocurarine, ACh hyperpolarised the cell membrane like a muscarinomimetic. The suggestion has been made that two kinds of cholinoreceptors (ChR) exist on the membrane of the LPed-2 neurone, differing in both the pharmacological properties and the ionic permeability changes they control3. Two different types of ChR have been described on the membrane of some identified Aplysia neurones4,5. Experiments3 performed on the LPed-2 neurone in the ganglionic ring where it receives synaptic inputs from various interneurones which also can respond to ACh do not exclude the possibility that the two kinds of responses are attributable to the interference of some interneurones masking the actual effect of ACh on the LPed-2 neurone.

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Authors and Affiliations

  1. Pharmacological Laboratory, Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad, Thorez pr. 52, 194223, USSR

    B. A. GER & ELLA V. ZEIMAL

Authors
  1. B. A. GER
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  2. ELLA V. ZEIMAL
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GER, B., ZEIMAL, E. Two kinds of cholinoreceptors on the membrane of the completely isolated identified Planorbarius corneus neurone. Nature 259, 681–684 (1976). https://doi.org/10.1038/259681a0

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