Abstract
INTEREST in haploid mouse embryos as a material for studying gene action in early development and as a potential source of haploid cell lines has stimulated a number of attempts to produce this condition experimentally. We describe here a new method of producing haploid mouse embryos by bisecting fertilised eggs. Morphologically normal haploid and haplo-diploid mosaic blastocysts were formed after insertion of such fragments to empty zonae and transfer to the oviduct.
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TARKOWSKI, A., ROSSANT, J. Haploid mouse blastocysts developed from bisected zygotes. Nature 259, 663–665 (1976). https://doi.org/10.1038/259663a0
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DOI: https://doi.org/10.1038/259663a0
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