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Naturally occurring antibody against unusually high serum DNA polymerase activity

Nature volume 259, pages 594–596 (1976)Cite this article

Abstract

WE have reported unusually high DNA polymerase activity in sera obtained from chimpanzees infected with the hepatitis B virus1, and Kaplan et al.2 reported hepatitis B-specific DNA polymerase activity in sera of human patients during post-transfusion hepatitis. We and others3–5 also found DNA polymerase activities associated with Dane particles, the putative hepatitis B virus, or their naked core components. Reports6,7 of the specific association of an e antigen-e antibody system with carriage of HBsAg prompted us to examine HBsAg positive sera containing unusually high levels of DNA polymerase activity for the presence of e antigen or e antibody. Subsequently, we studied the effects of sera containing e antibody on high DNA polymerase activity in sera from individuals with acute hepatitis B, chronic asymptomatic hepatitis B, chronic aggressive hepatitis B or chronic non-B hepatitis.

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Authors and Affiliations

  1. Phoenix Laboratories Division, Center for Disease Control, 4402 North Seventh Street, Phoenix, Arizonia, 85014

    D. W. BRADLEY, B. L. MURPHY, J. L. SMITH & J. E. MAYNARD

  2. Department of Medicine, School of Medicine, University of California Los Angeles Center for the Health Sciences, Los Angeles, California, 90024

    G. L. GITNICK

Authors
  1. D. W. BRADLEY
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  2. B. L. MURPHY
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  3. J. L. SMITH
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  4. J. E. MAYNARD
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  5. G. L. GITNICK
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BRADLEY, D., MURPHY, B., SMITH, J. et al. Naturally occurring antibody against unusually high serum DNA polymerase activity. Nature 259, 594–596 (1976). https://doi.org/10.1038/259594a0

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  • DOI: https://doi.org/10.1038/259594a0

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