Abstract
WHEN thyrotropin releasing hormone (TRH, pyroGlu–His–Pro–NH2) was isolated and its structure determined1,2 the concept of neurohumoral regulation of hormone secretion by the anterior pituitary3 was confirmed, but the mechanisms involved are not well understood. Enzymatic inactivation of TRH by blood and serum may regulate the hormone's activity by determining the number of molecules available to the thyrotroph4. With this physiological function, degradative enzyme(s) would itself need to be regulated and I report here that the activity of the TRH-degrading enzyme(s) is controlled by the thyroid hormones.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burgus, R., Dunn, T. F., Desiderio, D., and Guillemin, R., C. r. hebd. Séanc. Acad. Sci. Paris, D 289, 1870–1873 (1969).
Boler, J., Enzmann, F., Folkers, K., Bowers, C. Y., and Schally, A. V., Biochem. biophys. Res. Commun., 37, 705–510 (1969).
Harris, G. W., Neural Control of the Pituitary Gland (Arnold, London, 1955).
Burgus, R., et al., Nature, 226, 321–325 (1969).
Redding, T. W., and Schally, A. V., Proc. Soc. exp. Biol. Med., 131, 415–420 (1969).
Vale, W., Burgus, R., Dunn, T. F., and Guillemin, R., Hormones, 2, 193–203 (1971).
Bauer, K., Sy, J., and Lipmann, F., Fedn Proc. Abstr., 32, 489 (1973).
Redding, T. W., and Schally, A. V., Proc. Soc. exp. Biol. Med., 131, 420–425 (1969).
Tata, J. R., Biochem. J., 104, 1–10 (1967).
Guillemin, R., Yamazak, E., Card, D. A., Jutisz, M., and Sakis, E., Endocrinology, 73, 564 (1963).
Vale, W., Burgus, R., and Guillemin, R., Proc. Soc. exp. Biol. Med., 125, 210 (1967).
Schally, A. V., and Redding, T. W., Proc. Soc. exp. Biol. Med., 126, 320 (1967).
Rapp, J. R., and Pyun, L. L., Proc. Soc. exp. Biol Med., 146, 1021–1203 (1974).
Gershengorn, M. C., and Weintraub, B. D., J. clin. Invest., 56, 633–642 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BAUER, K. Regulation of degradation of thyrotropin releasing hormone by thyroid hormones. Nature 259, 591–593 (1976). https://doi.org/10.1038/259591a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/259591a0
This article is cited by
-
Advances in TRH signaling
Reviews in Endocrine and Metabolic Disorders (2016)
-
Single-compartment model analysis of thyrotropin-releasing hormone kinetics in hyper- and hypothyroid patients
Klinische Wochenschrift (1990)
-
Plasma levels of thyrotropin-releasing-hormone in various splanchnic, renal, suprarenal, and cerebral veins
Klinische Wochenschrift (1987)
-
Effect of unilateral or bilateral thyroidectomy on TRH content of hypothalamus halves
Journal of Endocrinological Investigation (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
