Abstract
IN VITRO binding of 3H-catecholamines to plasma membranes from a variety of tissues has been reported1–4. In none of these studies, however, has the binding satisfied criteria necessary for identification of true β adrenoceptors (for example, stereospecificity and high affinity for potent β-adrenoceptor antagonists). On the other hand studies using labelled β-adrenoceptor antagonists have demonstrated binding sites on erythrocyte ghosts and cardiac membranes that seem to satisfy fully the criteria associated with β adrenoceptors5–7.
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NAHORSKI, S. Association of high affinity stereospecific binding of 3H-propranolol to cerebral membranes with β adrenoceptors. Nature 259, 488–489 (1976). https://doi.org/10.1038/259488a0
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DOI: https://doi.org/10.1038/259488a0
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