Abstract
SINCE the pioneering work on regulation of the lac operon in Escherichia coli1 a great number of operator mutations have been described. In eukaryotic organisms, however, only a few mutations affecting cis-acting regulatory element (some of which can be formally interpreted as operator mutants) have been reported2–6. The term ‘operator’ in the case of eukaryotes is used in an operational sense as it is not known whether it describes a molecular organisation similar to that found in bacteria. This report describes a mutant of Aspergillus nidulans altered at a site closely linked to the sB gene for sulphate permease7. This mutation causes a hypersensitivity of this gene to repression by sulphur amino acids.
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LUKASZKIEWICZ, Z., PASZEWSKI, A. Hyper-repressible operator-type mutant in sulphate permease gene of Aspergillus nidulans. Nature 259, 337–338 (1976). https://doi.org/10.1038/259337a0
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DOI: https://doi.org/10.1038/259337a0
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