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Antibodies to native tRNA in NZB/NZW mice

Nature volume 259, pages 141–143 (1976)Cite this article

Abstract

ANTIBODIES to native DNA, double-stranded RNA, and various synthetic polyribonucleotides occur with great frequency in patients with systemic lupus erythematosus (SLE)1. These antibodies are also present in the New Zealand mouse, particularly the NZB/NZW F1 hybrid, which is considered a good animal model for human SLE2. We report here the presence and characterisation of antibodies that bind tRNA, specifically in its native conformation, in sera from old NZB/NZW mice.

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Authors and Affiliations

  1. Laboratory of Chemical Biology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    DAN EILAT & ALAN N. SCHECHTER

  2. Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    ALFRED D. STEINBERG

Authors
  1. DAN EILAT
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  2. ALAN N. SCHECHTER
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  3. ALFRED D. STEINBERG
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EILAT, D., SCHECHTER, A. & STEINBERG, A. Antibodies to native tRNA in NZB/NZW mice. Nature 259, 141–143 (1976). https://doi.org/10.1038/259141a0

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