Abstract
OESTROGEN has been shown to reduce S phase duration in uterine epithelial cells, although no agreement has been reached either on the exact values of cell cycle parameters, or even on the relative magnitude of the hormone-induced modifications1–6. It has also been shown that eukaryotic DNA molecules consist of replicative units arranged end-to-end, from the middle of which DNA synthesis proceeds bidirectionally at divergent fork growing points until fusion occurs with adjacent sections. The chain growth rate as well as the mean distance between initiation points were found to be specific for each cell type7–13. From this it can be inferred that oestrogen-dependent shortening of S phase in the uterine epithelium is due to speeding-up of replication along pre-existing units, or to multiplication of simultaneously operating replicative sections, or to both these mechanisms. The results that we have obtained from autoradiography of DNA fibres confirm that oestrogen increases the rate of DNA fork replication.
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LEROY, F., BOGAERT, C. & HOECK, J. DNA replication and accelerated chain growth in oestrogen-stimulated uterine cells. Nature 258, 259–260 (1975). https://doi.org/10.1038/258259a0
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DOI: https://doi.org/10.1038/258259a0
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