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Genetics of natural resistance to herpesvirus infections in mice

Nature volume 258, pages 152–153 (1975)Cite this article

Abstract

INHERITED resistance to virus infections has been demonstrated in several murine systems1–6. Susceptibility to mouse hepatitis virus3 and resistance to arbovirus7 infections in mice are dominant traits associated with the capacity of macrophages from the susceptible strains to replicate virus. Resistance to Friend leukaemia virus- and Gross leukaemia virus-induced leukaemogenesis is determined by at least two genes, one closely linked to the immune response genes of the mouse8. Conversely, susceptibility to lymphocytic choriomeningitis (LCM) virus infections in mice has been associated with a gene closely linked to the immune response genes9. The latter seems to be associated with the cell-mediated immune response to LCM which causes tissue damage and leads to death. Cell-mediated immunity seems to be important in resistance against herpes simplex virus (HSV) infections10–12. Analysis of the aspects of cell-mediated immunity which might be involved in resistance in man is complicated by the uncontrollable factors associated with activation of latent herpesvirus infections. I have developed a mouse model which has shown that at least three genes are responsible for resistance to HSV. Although preliminary evidence suggests that resistance is immunologically mediated, resistance genes do not seem to be closely linked to the histocompatibility region of the mouse.

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  1. Sloan–Kettering Institute, Laboratory of Slow-Virus Infections, 410 East 68th Street, New York, New York, 10021

    CARLOS LOPEZ

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  1. CARLOS LOPEZ
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LOPEZ, C. Genetics of natural resistance to herpesvirus infections in mice. Nature 258, 152–153 (1975). https://doi.org/10.1038/258152a0

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