Abstract
THE fundamental defect in Duchenne muscular dystrophy is obscure. Early investigators attributed the disorder to a primary defect of the skeletal muscle itself,1 but alternative suggestions have implicated the motor neurone2,3 or the vascular supply4. Recent attention has been directed to the plasma membrane of muscle as well as of other tissues. Several authors have postulated a generalised membrane defect as the fundamental problem in this disorder5–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Walton, J. N., Br. Med. J., 1, 1271 (1964).
Gallup, B., and Dubowitz, V., Nature, 243, 287 (1973).
McComas, A. J., Sica, R. E. P., and Currie, S., Nature, 226, 1263 (1964).
Hathaway, P. W., Engel, W. K., and Zellweger, H., Archs Neurol., 22, 365 (1970).
Rodan, S. B., Hintz, R. L., Sha'afi, R. I., and Rodan, G. A., Nature, 252, 589 (1974).
Matheson, D. W., and Howland, J. L., Science, 184, 165 (1974).
Roses, A. D., Herbstreith, M. H., and Appel, S. H., Nature, 254, 350 (1975).
Weed, R. I., and Chailley, B., Nouvelle Rev. Francaise d'Hemat., 12, 775 (1972).
Mitchison, J. M., and Swann, M. M., J. exp. Biol., 31, 443 (1954).
Miller, M. E., Sem. Hematol., 12, 59 (1975).
Weed, R. I., LaCelle, P. L., Merrill, E. W., J. clin. Invest., 48, 795 (1969).
Miller, M. E., Myers, K. A., Fedn Proc., 34, 269 (1975).
Wins, P., and Schoffeniels, E., Biochim. biophys. Acta, 120, 341 (1966).
Rosenthal, A. S., Kregenow, F. M., and Moses, H. L., Biochim. biophys. Acta, 196, 254 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PERCY, A., MILLER, M. Reduced deformability of erythrocyte membranes from patients with Duchenne muscular dystrophy. Nature 258, 147–148 (1975). https://doi.org/10.1038/258147a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/258147a0
This article is cited by
-
Dielectrophoretic force measurement of red blood cells exposed to oxidative stress using optical tweezers and a microfluidic chip
Biomedical Engineering Letters (2017)
-
Osmotic fragility of erythrocytes in myopathies
Journal of Neurology (1981)
-
Erythrocyte ghost (Na+ + K+) ATPase activity in mice with hereditary muscular dystrophy (strain C57 BL 6 J/dy)
Journal of Neurology (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
