Abstract
IT is well established that potent interferon preparations besides inducing antiviral activity1, inhibit growth of homologous cells in culture2–4. In addition, interferon increases the susceptibility of cells to the toxic effects of synthetic double-stranded RNA5 and to sensitised lymphocytes6, enhances phagocytic activity7 and stimulates interferon production by priming8. In most studies a close correlation was found between antiviral and non-antiviral activities. The correlation is independent of the degree of purification, and efforts at separation have largely been unsuccessful2,5,8,9, indicating that the effects are attributable to the same substance.
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DAHL, H., DEGRE, M. Separation of antiviral activity of human interferon from cell growth inhibitory effect. Nature 257, 799–801 (1975). https://doi.org/10.1038/257799a0
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DOI: https://doi.org/10.1038/257799a0
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