Letter | Published:

Noradrenaline induces morphological alterations in nucleated and enucleated rat C6 glioma cells

Nature volume 257, pages 317319 (25 September 1975) | Download Citation

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Abstract

GILMAN and Nirenberg1 have reported that catecholamines induce a striking increase in intracellular cyclic AMP concentration in cultures of rat and human glioma cells. They concluded that this activation of the adenylate cyclase was mediated through the β-adrenergic receptor, since the effect was inhibited by the β-receptor blockers sotalol and dichloroiso-proterenol. Another report2 showed that cultured human glioma cells treated with cyclic AMP derivatives resumed the typical morphology of the normal counterparts, that is, having multiple processes extending from a compact cell body. I have therefore compared the effects of noradrenaline, a β-adrenergic stimulator, on the morphology and cyclic AMP level in rat C6 glioma cells.

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Affiliations

  1. Universität Konstanz, Fachbereich Biologie, D-775 Konstanz, West Germany

    • JAN OEY

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DOI

https://doi.org/10.1038/257317a0

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