Abstract
GILMAN and Nirenberg1 have reported that catecholamines induce a striking increase in intracellular cyclic AMP concentration in cultures of rat and human glioma cells. They concluded that this activation of the adenylate cyclase was mediated through the β-adrenergic receptor, since the effect was inhibited by the β-receptor blockers sotalol and dichloroiso-proterenol. Another report2 showed that cultured human glioma cells treated with cyclic AMP derivatives resumed the typical morphology of the normal counterparts, that is, having multiple processes extending from a compact cell body. I have therefore compared the effects of noradrenaline, a β-adrenergic stimulator, on the morphology and cyclic AMP level in rat C6 glioma cells.
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References
Gilman, A. G., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 68, 2165–2168 (1971).
Edström, A., Kanje, M., and Walum, E., Expl Cell Res., 85, 217–223 (1974).
Benda, P., Lightbody, J., Sato, G., Levine, L., and Sweet, W., Science, 161, 370–370 (1968).
Prescott, D. M., Myerson, D., and Wallace, J., Expl Cell Res., 71, 480–485 (1972).
Gilman, A. G., Proc. natn. Acad. Sci. U.S.A., 67, 305–312 (1970).
Puck, T. T., Waldren, C. A., and Hsie, A. W., Proc. natn. Acad. Sci. U.S.A., 69, 1943–1947 (1972).
Schröder, C. H., and Hsie, A. W., Nature new Biol., 246, 58–60 (1973).
Goodman, D. B. P., Rasmussen, H., DiBella, F., and Guthrow, C. E., Jr, Proc. natn. Acad. Sci. U.S.A., 67, 652–659 (1970).
Gaskin, F., Cantor, C. R., and Shelankski, M. L., J. molec. Biol., 89, 737–758 (1974).
Weber, K., Pollack, R., and Bibring, T., Proc. natn. Acad. Sci. U.S.A., 72, 459–463 (1975).
Goldman, R. D., Pollack, R., and Hopkins, N. H., Proc. natn. Acad. Sci. U.S.A., 70, 750–754 (1973).
Miller, R. A., and Ruddle, F. H., J. Cell Biol., 63, 295–299 (1974).
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OEY, J. Noradrenaline induces morphological alterations in nucleated and enucleated rat C6 glioma cells. Nature 257, 317–319 (1975). https://doi.org/10.1038/257317a0
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DOI: https://doi.org/10.1038/257317a0
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