Letter | Published:

Spontaneous AKR lymphoma with T and B-cell characteristics

Nature volume 257, pages 314316 (25 September 1975) | Download Citation

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Abstract

THE existence of surface immunoglobulin on thymus-derived cells (T cells) has been difficult to demonstrate and is still controversial1–6. Therefore the presence of easily detectable surface immunoglobulin (sIg) is considered to be a reliable marker for lymphoid cells of bone marrow origin (B cells)7. To our knowledge no cell line has been reported to bear both easily detectable sIg (that is, by immunofluorescent staining) and T-cell markers, although two murine T-cell lines have been reported to bear small amounts of sIg detectable only by extremely sensitive methods (2,8). We now report the existence of a murine lymphoma line with both T and B-cell characteristics by the criteria of easily detectable sIg, presence of Thy1.1 (θ AKR) antigen9, and mitogen responsiveness.

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Affiliations

  1. Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

    • ROBERT S. GREENBERG
    •  & MARION M. ZATZ

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DOI

https://doi.org/10.1038/257314a0

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