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Kinetics of inactivation of histone mRNA in the cytoplasm after inhibition of DNA replication in synchronised HeLa cells

Naturevolume 257pages247248 (1975) | Download Citation



IN many eukaryotic cells DNA replication and histone synthesis proceed synchronously1–6. Interruption of DNA synthesis in synchronised HeLa cells results in an immediate decrease of histone synthesis as measured by incorporation of labelled amino acids into histones2,3 or by following the completion of nascent histone poly pep tide chains on polyribosomes in vitro5.

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  1. Physiologisch-Chemisches Institut der Universität Marburg, Lahnberge, 355, Marburg/Lahn, West Germany



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