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Cytocidal and cytostatic effects of activated peritoneal leukocytes

Nature volume 257, pages 228–229 (1975)Cite this article

Abstract

MACROPHAGES seem to be of importance in both immunologically specific and nonspecific resistance to neoplastic cells1–10. It has been proposed11–13 that activated macrophages are significant effectors in the elimination of tumour cells at sites of delayed hypersensitivity reactions induced by chemical haptens, microbial antigens or lymphokines13–18. Immunologically specific elimination of neoplastic cells by macrophages may be mediated by tumour-specific antibodies7,10,19,20. Such antibodies may also confer specificity to macrophages activated by nonspecific stimulation. Besides specificity which may be imparted by antibodies, activated macrophages seem to possess an inherent recognition mechanism which permits selective cytotoxicity towards certain categories of cells, including tumour cells11,21–23.

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References

  1. Amos, D. B., Ann. N. Y. Acad. Sci., 87, 273–292 (1960).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., and Stockert, E., Cancer Res., 21, 1281–1300 (1961).

    CAS  PubMed  Google Scholar 

  3. Baker, P., Weiser, R. S., Jutila, J., Evans, C. A., and Blandau, R. J., Ann. N. Y. Acad. Sci., 101, 46–63 (1962).

    Article  ADS  Google Scholar 

  4. Granger, G. A., and Weiser, R. S., Science, 145, 1427–1429 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Bennett, B., J. Immun., 95, 656–664 (1965).

    CAS  PubMed  Google Scholar 

  6. Zbar, B., Bernstein, I. D., and Rapp, H. J., J. natn. Cancer Inst., 46, 831–839 (1971).

    CAS  Google Scholar 

  7. Evans, R., and Alexander, P., Transplantation, 12, 227–229 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. Keller, R., J. exp. Med., 138, 625–644 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Krahenbuhl, J. L., and Remington, J. S., J. Immun., 113, 507–516 (1974).

    CAS  PubMed  Google Scholar 

  10. Evans, R., and Alexander, P., Nature, 236, 168–170 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Holtermann, O. A., Lisafeld, B. A., and Klein, E., J. exp. clin. Med., 3, 359–362 (1972).

    CAS  Google Scholar 

  12. Holtermann, O. A., Casale, G. P., and Klein, E., J. exp. clin. Med., 3, 305–309 (1972).

    CAS  Google Scholar 

  13. Klein, E., and Holtermann, O. A., Natn. Cancer Inst. Monogr., 35, 379–402 (1972).

    CAS  Google Scholar 

  14. Klein, E., Cancer Res., 29, 2351–2362 (1969).

    CAS  PubMed  Google Scholar 

  15. Levis, H. B., Kramer, K. H., Klinger, W. G., Peck, G. L., and Terry, W. D., Cancer Res., 33, 3036–3040 (1973).

    CAS  PubMed  Google Scholar 

  16. Holtermann, O. A., Papermaster, B., Rosner, D., Milgrom, H., and Klein, E., J. exp. clin. Med., 6, 157–168 (1975).

    CAS  Google Scholar 

  17. Bernstein, D., Thor, D., Zbar, B., and Rapp, H., Science, 172, 729–731 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Papermaster, B., Holtermann, O. A., Rosner, D., Klein, E., and Dao, T., Res. Commun. chem. Path. Pharm., 8, 413–416 (1974).

    CAS  PubMed  Google Scholar 

  19. Fakhri, O., McLaughlin, H., and Hobbs, J. R., Eur. J. Cancer, 9, 19–23 (1973).

    Article  CAS  PubMed  Google Scholar 

  20. Perlmann, P., and Holm, G., Adv. Immun., 11, 112–193 (1969).

    Google Scholar 

  21. Hibbs, J. B., Jr, Lambert, L. H., and Remington, J. S., Proc. Soc. exp. Biol. Med., 139, 1049–1052 (1972).

    Article  PubMed  Google Scholar 

  22. Hibbs, J. B., Jr, Lambert, L. H., and Remington, J. S., Science, 177, 998–100 (1972).

    Article  ADS  PubMed  Google Scholar 

  23. Holtermann, O. A., Klein, E., and Casale, G. P., Cell. Immun. 9, 339–352 (1973).

    Article  CAS  Google Scholar 

  24. McLaughlin, J. F., Ruddle, N. H., and Waksman, B. H., J. Reticuloendoth. Soc., 12, 293–304 (1972).

    CAS  Google Scholar 

  25. Ruddle, N. H., In Vitro Methods in Cell Mediated Immunity (edit. by Bloom, B. R., and Glade, P. R.), (Academic, New York, 1971).

    Google Scholar 

  26. Cleveland, R. P., Meltzer, M. S., and Zbar, B., J. natn. Cancer Inst., 52, 1887–1895 (1974).

    Article  CAS  Google Scholar 

  27. Fox, T., Sheppard, J. R., and Burger, M. M., Proc. natn. Acad. Sci., 68, 244–247 (1971).

    Article  ADS  CAS  Google Scholar 

  28. Saunders, J. W., Science, 154, 604–612 (1966).

    Article  ADS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Dermatology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, New York, 14263

    OLE A. HOLTERMANN, BARBARA A. LISAFELD, EDMUND KLEIN & JIMMY KLOSTERGAARD

  2. Department of Dermatology, State University of New York at Buffalo, New York, 14215

    OLE A. HOLTERMANN, BARBARA A. LISAFELD, EDMUND KLEIN & JIMMY KLOSTERGAARD

Authors
  1. OLE A. HOLTERMANN
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  2. BARBARA A. LISAFELD
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  3. EDMUND KLEIN
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  4. JIMMY KLOSTERGAARD
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HOLTERMANN, O., LISAFELD, B., KLEIN, E. et al. Cytocidal and cytostatic effects of activated peritoneal leukocytes. Nature 257, 228–229 (1975). https://doi.org/10.1038/257228a0

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