Letter | Published:

Permeability of solutes through biological membranes measured by a desorption technique

Nature volume 257, pages 225227 (18 September 1975) | Download Citation

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Abstract

THE influence of molecular structure of a solute on its permeation through biological membranes has been evaluated by various methods1–4. For permeation of a solute across a membrane of thickness, h, the permeability coefficient, P, can be expressed in terms of the membrane–solution partition coefficient (K m) and the diffusion coefficient in the membrane (D): P=K m D/h (1)

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Author information

Affiliations

  1. Department of Pharmacy, University of Sydney, New South Wales 2006, Australia

    • M. S. ROBERTS
    • , E. J. TRIGGS
    •  & R. A. ANDERSON

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DOI

https://doi.org/10.1038/257225a0

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