Letter | Published:

Nerves and angiogenesis in amphibian limb regeneration

Nature volume 257, pages 224225 (18 September 1975) | Download Citation

Subjects

Abstract

IN the past 150 yr, since the requirement of nerves for amphibian limb regeneration was demonstrated, there has been considerable progress in specifying the nature of the phenomenon but virtually none in understanding the site or nature of the neuronal effect1. If denervation is carried out early, amputated limbs will not regenerate and may even undergo regression; at later stages in regeneration, when a blastema has formed, regeneration is not prevented by denervation, although in the newt at least, growth in volume is inhibited while growth in length and morphogenesis continue2,3. Studies on the neuronal dependence have shown that any nerve can provide the trophic influence, that neither central nor reflex circuitry is required, and that a threshold number of nerves at the amputation surface is needed4. The neurotrophic agents do not determine the nature of the regenerate but only its growth properties4, and this is borne out by many biochemical studies, all of which suggest that nerves nonspecifically affect macromolecular synthesis and cell division5,6.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Q. Rev. Biol., 27, 169–200 (1952).

  2. 2.

    , and , J. exp. Zool., 108, 279–308 (1948).

  3. 3.

    , Advances in Morphogenesis (edit. by Abercrombie, M., and Brachet, J.), 7, 205–249 (Academic, New York, 1968).

  4. 4.

    , Ann. N. Y. Acad. Sci., 228, 308–322 (1974).

  5. 5.

    , and , J. exp. Zool., 190, 317–327 (1974).

  6. 6.

    , and , J. Embryol. exp. Morph., 28, 1–11 (1972).

  7. 7.

    , in Macromolecules Regulating Growth and Development (edit. by Hay, E. D., King, T. J., and Papaconstantinou, J.), 43–52 (Academic, New York, 1974).

  8. 8.

    , , , and , J. Embryol. exp. Morph., 32, 375–390 (1974).

  9. 9.

    , and , J. Morph., 118, 79–90 (1966).

  10. 10.

    , J. exp. Zool., 170, 125–148 (1969).

  11. 11.

    , and , C. r. hebd. Séanc. Acad. Sci. Paris, 280, 1409–1411 (1975).

  12. 12.

    , and , Natn. Cancer Inst. Monogr., 38, 29–36 (1973).

Download references

Author information

Affiliations

  1. Department of Biology as Applied to Medicine, The Middlesex Hospital Medical School, London W1P 6DB, UK

    • A. R. SMITH
    •  & L. WOLPERT

Authors

  1. Search for A. R. SMITH in:

  2. Search for L. WOLPERT in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/257224a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.