Abstract
A model for the evolution of insulin mainly in terms of adaptive processes is discussed. The model depends critically on the relationship of sequence changes to the three-dimensional structure and the role of various parts of this structure in the conversion of the proinsulin molecule to the active form, the storage of insulin, its transport to the site of action and its interaction with a receptor.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Darwinian, Neo-Darwinian Evolution, Proc. sixth Berkeley Symp., 5, (edit. by Le Cam, L. M., Neyman, J., and Scott, E. L.) (University of California Press, Berkeley and Los Angeles, 1972).
Smith, E. L., in The Enzymes (edit. by Boyer, P. D.), 1, 267–314 (Academic New York, 1970).
Kimura, M., Nature, 217, 624–626 (1968).
King, J. L., and Jukes, T. H., Science, 164, 788–798 (1969).
Markussen, J., and Volund, A., Int. J. Peptide Protein Res., 6, 79–86 (1974).
Smith, L. F., Diabetes, 21, Suppl. 2, 457–460 (1972).
Adams, M. J., et al., Nature, 224, 491–495 (1969).
Blundell, T. L., Dodson, G. G., Dodson, E. J., Hodgkin, D. C., and Vijayan, M., Rec. Prog. Hormone Res., 27, 1–40 (1971).
Blundell, T. L., Dodson, G. G., Hodgkin, D. C., and Mercola, D. A., Adv. Protein Chem., 26, 279–402 (1972).
Steiner, D. F., and Oyer, P. E., Proc. natn. Acad. Sci. U.S.A., 57, 473–480 (1967).
Grieder, M. H., Howell, S. L., and Lacy, P. E., J. Cell Biol., 41, 162–166 (1969).
Lange, R. H., Diabetologia, 7, 465–466 (1971).
Gavin, J. R., III, Gorden, P., Roth, J., Archer, J. A., Buell, D. N., J. biol. Chem., 248, 2202–2207 (1973).
Gammettoft, S., and Gliemann, J., Biochem. biophys. Acta, 320, 16–32 (1973).
Preychett, P., Roth, J., and Neville, D. M., Proc. natn. Acad. Sci. U.S.A., 68, 1833–1837 (1971).
Falkmer, S., in Ostman, J., Diabetes, Proc. sixth Cong. Int. Diabetes Fed., 55–66 (Excerpta Medica Foundation, Amsterdam, 1969).
Frank, B. H., and Veros, A. J., Biochem. biophys. Res. Commun., 38, 284–289 (1970).
Grant, P. T., Coombs, T. L., and Franks, B. H., Biochem. J., 126, 433 (1972).
Baker, E. N., and Dodson, G. G., J. molec. Biol., 54, 605 (1970).
Cutfield, J. F., Cutfield, S. M., Dodson, E. J., Dodson, G. G., and Sabesan, M. N., J. molec. Biol., 87, 23–30 (1974).
Peterson, J. D., Coulter, C. L., Steiner, D. F., Emdin, S. O., and Falkmer, S., Nature, 251, 239–240 (1974).
Zimmerman, A. E., and Yip, C. C., J. biol. Chem., 249, 4021–4036 (1974).
Wood, S. P., Blundell, T. L., Wollmer, A., Lazarus, N. R., and Neville, R. W. J., Eur. J. Biochem. (in the press).
Neville, R. W. J., Weir, B. J., and Lazarus, N. R., Diabetes, 22, 851–853 (1973).
Dayhoff, M. O., Atlas of Protein Sequence and Structure, 5, D210–D211 (1972).
Markussen, J., and Sunby, F., Int. J. Peptide Protein Res., 5, 37–38 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Blundell, T., Wood, S. Is the evolution of insulin Darwinian or due to selectively neutral mutation?. Nature 257, 197–203 (1975). https://doi.org/10.1038/257197a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/257197a0
This article is cited by
-
Evolutionary biochemistry: revealing the historical and physical causes of protein properties
Nature Reviews Genetics (2013)
-
Structural and functional constraints in the evolution of protein families
Nature Reviews Molecular Cell Biology (2009)
-
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
Biology Direct (2007)
-
Missense meanderings in sequence space: a biophysical view of protein evolution
Nature Reviews Genetics (2005)
-
Quantifying Structural and Functional Restraints on Amino Acid Substitutions in Evolution of Proteins
Biochemistry (Moscow) (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.