Review Article | Published:

Opiate receptor in normal and drug altered brain function*

Naturevolume 257pages185189 (1975) | Download Citation

Subjects

Abstract

Recent biochemical identification of the receptor site for pharmacological actions of opiates helps elucidate how these drugs relieve pain, elicit euphoria and ‘addiction’, and provides simple, direct approaches to developing potentially non-addicting analgesics. The isolation of a morphine-like peptide which may be a central nervous system neurotransmitter sheds light on normal brain mechanisms regulating pain and emotion.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Goldstein, A., Lowney, L. L., and Pal, B. K., Proc. natn. Acad. Sci. U.S.A., 68, 1742–1747 (1971).

  2. 2

    Pert, C. B., and Snyder, S. H., Science, 179, 1011–1014 (1973).

  3. 3

    Pert, C. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 70, 2243–2247 (1973).

  4. 4

    Terenius, L., Acta Pharmacol. Toxicol., 32, 317–320 (1973).

  5. 5

    Simon, E. J., Hiller, J. M., and Edelman, I., Proc. natn. Acad. Sci. U.S.A., 70, 1947–1949 (1973).

  6. 6

    Snyder, S. H., Pasternak, G. W., and Pert, C. B., in Handbook of Psychopharmacology (edit. by Iversen, L. L., Iversen, S. D., and Snyder, S. H.), 329–360. (Plenum, New York, 1975).

  7. 7

    Loh, H. H., Cho, T. M., Wu, Y.-C., and Way, E. L., Life Sci., 14, 2231–2245 (1974).

  8. 8

    Abood, L. G.,, Hoss, W. P., Psychopharmacol. Commun., 1, 29–36 (1975).

  9. 9

    Paton, W. D. M., Br. J. Pharmac. Chemother., 12, 119–127 (1957).

  10. 10

    Kosterlitz, H. W., and Waterfield, A. A., A. Rev. Pharmac., 15, 29–47 (1975).

  11. 11

    Creese, I., and Snyder, S. H., J. Pharmac. exp. Ther., 194, 205–219 (1975).

  12. 12

    Lasagna, L., Pharmac. Rev., 16, 47–83 (1964).

  13. 13

    Pert, C. B., Pasternak, G. W., and Snyder, S. H., Science, 182, 1359–1361 (1973).

  14. 14

    Pert, C. B., and Snyder, S. H., Molec. Pharmac., 10, 868–879 (1974).

  15. 15

    Simon, E. J., Hiller, J. M., Groth, J., and Edelman, I., J. Pharmac. exp. Ther., 192, 531–537 (1975).

  16. 16

    Pasternak, G. W., and Snyder, S. H., Nature, 253, 563–565 (1975).

  17. 17

    Snyder, S. H., Neurosci. Res. Prog. Bull., 13, 137–141 (1975).

  18. 18

    Pasternak, G. W., and Snyder, S. H., Molec. Pharmac., 10, 183–193 (1974).

  19. 19

    Pasternak, G. W., and Snyder, S. H., Molec. Pharmac., 11, 478–484 (1975).

  20. 20

    Pasternak, G. W., Wilson, H. A., and Snyder, S. H., Molec. Pharmac., 11, 340–351 (1975).

  21. 21

    Wilson, H. A., Pasternak, G. W., and Snyder, S. H., Nature, 253, 448–450 (1975).

  22. 22

    Pasternak, G. W., Snowman, A., and Snyder, S. H., Molec. Pharmac. (in the press).

  23. 23

    Karlin, A., J. theor. Biol., 16, 306–320 (1967).

  24. 24

    Changeux, J. -P., and Podleski, T. R., Proc. natn. Acad. Sci. U.S.A., 59, 944–950 (1968).

  25. 25

    Snyder, S. H., Biochem. Pharmac., 24, 1371–1374 (1975).

  26. 26

    Young, A. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 70, 2832–2836 (1973).

  27. 27

    Young, A. B., and Snyder, S. H., Proc. natn. Acad. Sci. U.S.A., 71, 4002–4005 (1974).

  28. 28

    Nauta, W. J. H., Neurosci. Res. Prog. Bull., 13, 84–87 (1975).

  29. 29

    Kuhar, M. J., Pert, C. B., and Snyder, S. H., Nature, 245, 447–450 (1973).

  30. 30

    Hiller, J. M., Pearson, J., and Simon, E. J., Res. Commun. chem. pathol. Pharmac., 6, 1052–1062 (1973).

  31. 31

    Pert, A., and Yaksh, T., Brain Res., 80, 135–140 (1974).

  32. 32

    Wei, E. L., Loh, H. H., and Way, E. L., J. pharmac. exp. Ther., 185, 108–115 (1973).

  33. 33

    Pert, C. B., Kuhar, M. J., and Snyder, S. H., Life Sci., 16, 1849–1854 (1975).

  34. 34

    Pert, C. B., and Snyder, S. H., Life Sci., 16, 1623–1634 (1975).

  35. 35

    Korf, J., Bunney, B. S., and Aghajanian, G. K., Eur. J. Pharmac., 25, 165–169 (1974).

  36. 36

    way, E. L., Neurosci. Res. Prog. Bull., 13, 112–118 (1975).

  37. 37

    Pert, C. B., Aposhian, D., and Snyder, S. H., Brain Res., 75, 356–361 (1974).

  38. 38

    Pert, C. B., Snowman, A. M., and Snyder, S. H., Brain Res., 70, 184–188 (1974).

  39. 39

    Hughes, J., Brain Res., 88, 1–14 (1975).

  40. 40

    Terenius, L., and Wahlström, A., Life Sci., 16, 1759–1764 (1975).

  41. 41

    Pasternak, G. W., Goodman, R., and Snyder, S. H., Life Sci., 16, 1765–1769 (1975).

  42. 42

    Hughes, J., Life Sci. (in the press).

  43. 43

    Teschmacher, H., Opheim, K., Cox, B. M., and Goldstein, A., Life Sci., 16, 1771–1776 (1975).

  44. 44

    Satoh, M., Zieglgansberger, F. W., and Herz, A., Brain Res., 82, 378–382 (1974).

  45. 45

    Cochin, J., Fedn Proc., 29, 19–27 (1974).

  46. 46

    Collier, H. O. J., Adv. Drug Res., 3, 171–188 (1966).

  47. 47

    Goldstein, D. B., and Goldstein, A., Biochem. Pharmac., 8, 48 (Abstr. No. 152) (1961).

  48. 48

    Shuster, L., Nature, 189, 314–315 (1961).

  49. 49

    Martin, W. R., Fedn Proc., 29, 13–18 (1970).

  50. 50

    Klee, W. A., and Streaty, R. A., Nature, 248, 61–63 (1974).

  51. 51

    Klee, W. A., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 71, 3474–3477 (1974).

  52. 52

    Sharma, S. K., Nirenberg, M., and Klee, W. A., Proc. natn. Acad. Sci. U.S.A., 72, 590–594 (1974).

  53. 53

    Traber, J., Gullis, R., and Hamprecht, B., Life Sci., 16, 1863–1868 (1975).

  54. 54

    Klee, W. A., Sharma, S. K., and Nirenberg, M., Life Sci. (in the press).

  55. 55

    Collier, H. O. J., and Roy, A. C., Nature, 248, 24–27 (1974).

  56. 56

    Collier, H. O. J., Francis, D. L., Henderson, G., and Schneider, C., Nature, 249, 471–473 (1974).

  57. 57

    Francis, D. L., Roy, A. C., and Collier, H. O. J., Life Sci., 16, 1901–1906 (1975).

Download references

Author information

Affiliations

  1. Departments of Pharmacology and Experimental Therapeutics, and Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    • Solomon H. Snyder

Authors

  1. Search for Solomon H. Snyder in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/257185a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.