Abstract
IN recent years, a precursor–product relationship between heterogeneous nuclear RNA (HnRNA) and cytoplasmic messenger RNA (mRNA) has been investigated intensively1,2. The HnRNA was shown to have a double-stranded hairpin structure within its long molecules3–5. This particular region has been isolated as a double-stranded RNA (dsRNA) after treatment with ribonucleases, followed by purification on cellulose5 or hydroxyapatite3,4. The HnRNA of higher organisms is degraded largely in the nucleus and, at most, 10% of the nuclear content is transported to the cytoplasm2. It remains unknown whether the double-stranded structures in the HnRNA molecules are totally degraded in the nucleus or whether sequences involved in this structure are preserved in part or in toto during nuclear processing and possibly become parts of cytoplasmic mRNA.
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NAORA, H., WHITELAM, J. Presence of sequences hybridisable to dsRNA in cytoplasmic mRNA molecules. Nature 256, 756–759 (1975). https://doi.org/10.1038/256756a0
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DOI: https://doi.org/10.1038/256756a0
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