Letter | Published:

Scrapie incubation time can exceed natural lifespan

Naturevolume 256pages732733 (1975) | Download Citation

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Abstract

IN mice injected with mouse-passaged scrapie, the earliest rise in titre of agent is found in organs of the lymphoreticular system—irrespective of whether the injection is intracerebral or by a peripheral route1–4. The titre of agent in the spleen, for example, can rise fairly quickly to a moderate plateau level and subsequently starts to increase progressively in the brain, where it reaches, during the clinical phase, a greater concentration than elsewhere. These generalisations are based on work in various laboratories with agent strain–mouse strain combinations having relatively short incubation periods in the range 150–300 d after injection of high doses of agent. Evidence of replication in the spleen is therefore an indication that the animal will eventually develop scrapie if it lives long enough.

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References

  1. 1

    Eklund, C. M., Kennedy, R. C., and Hadlow, W. J., J. infect. Dis., 117, 15 (1967).

  2. 2

    Dickinson, A. G., and Fraser, H., J. comp. Path., 79, 363 (1969).

  3. 3

    Clarke, M. C., and Haig, D. A., Res. vet. Sci., 12, 195 (1971).

  4. 4

    Hunter, G. D., Kimberlin, R. H., and Millson, G. C., Nature new Biol., 235, 31 (1972).

  5. 5

    Dickinson, A. G., Genetics, 79, 387 (1975).

  6. 6

    Outram, G. W., Dickinson, A. G., and Fraser, H., Nature, 241, 536 (1973).

  7. 7

    Dickinson, A. G., and Meikle, V. M. H., Molec. gen. Genet., 121, 73 (1971).

  8. 8

    Fraser, H., Proc. sixth Int. Congr. Neuropath., 897 (Masson, Paris, 1970).

  9. 9

    Dickinson, A. G., Fraser, H., Meikle, V. M. H., and Outram, G. W., Nature new Biol., 237, 244 (1972).

  10. 10

    Outram, G. W., in Slow Virus Diseases, ch. 14 (edit. by Kimberlin, R. H.) (Elsevier, Amsterdam, in the press).

  11. 11

    Duffy, P., Wolf, J., Collins, G., De Voe, A. G., Streeten, B., and Cowen, D., New Engl. J. Med., 290, 692 (1974).

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Author information

Affiliations

  1. ARC Animal Breeding Research Organisation, Edinburgh, EH9 3JQ

    • A. G. DICKINSON
    • , H. FRASER
    •  & G. W. OUTRAM
  2. Moredun Research Institute, Edinburgh, EH17 7JH, UK

    • A. G. DICKINSON
    • , H. FRASER
    •  & G. W. OUTRAM

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https://doi.org/10.1038/256732a0

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