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Agonism and antagonism of γ-aminobutyric acid

Naturevolume 256pages600602 (1975) | Download Citation

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Abstract

EVIDENCE that (+)bicuculline (BIC) is a competitive antagonist of the central inhibitory transmitter γ-aminobutyric acid (GABA) is based1 mainly on apparent similarities between the molecular structures of BIC, GABA and agonists of GABA. Until recently, there has not been any explanation of the differing potencies of the agonists, or why BIC is an antagonist instead.

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References

  1. 1

    Curtis, D. R., Duggan, A. W., Felix, D., and Johnston, G. A. R., Nature, 226, 1222 (1970).

  2. 2

    Steward, E. G., Player, R. B., Quilliam, J. P., Brown, D. A., and Pringle, M. J., Nature new Biol., 233, 87 (1971).

  3. 3

    Beart, P. M., Curtis, D. R., and Johnston, G. A. R., Nature new Biol., 234, 80 (1971).

  4. 4

    Johnston, G. A. R., et a.l, J. Neurochem., 24, 157 (1975).

  5. 5

    Kier, L. B., and Truitt, E. B., Experientia, 26, 988 (1970).

  6. 6

    Kier, L. B., and George, J. M., Experientia, 29, 501 (1973).

  7. 7

    Kier, L. B., George, J. M., and Höltje, H.-D., J. Pharmaceut. Sci., 63, 1435 (1974).

  8. 8

    Kier, L. B., Molecular Orbital Theory in Drug Research (Academic, New York, 1971).

  9. 9

    Warner, D., and Steward, E. G., J. molec. Struct., 25, 403 (1975).

  10. 10

    Pullman, B., and Berthod, H., C. r. hebd. Séanc. Acad. Sci., Paris, 278, 1433 (1974).

  11. 11

    Pullman, B., and Berthod, H., Theor. chim. Acta, 36, 317 (1975).

  12. 12

    Steward, E. G., and Clarke, G. R., J. theoret. Biol. (in the press).

  13. 13

    Gilardi, R. D., Nature new Biol., 245, 86 (1973).

  14. 14

    Gorinsky, C., and Moss, D. S., J. Cryst. molec. Struct., 3, 299 (1973).

  15. 15

    Steward, E. G., Player, R. B., and Warner, D., Nature new Biol., 245, 88 (1973).

  16. 16

    Johnston, G. A. R., and Curtis, D. R., Nature, 248, 804 (1974).

  17. 17

    Snatzke, G., et al., Tetrahedron, 25, 5059 (1969).

  18. 18

    Andrews, P. R., and Johnston, G. A. R., Nature new Biol., 243, 29 (1973).

  19. 19

    Swagel, M. W., Ikeda, K., and Roberts, E., Nature new Biol., 246, 91 (1973).

  20. 20

    Warner, D., Player, R. B., and Steward, E. G., Int. Union of Crystallography First European Meeting, B 4, (1973).

  21. 21

    Collins, J. F., and Hill, R. G., Nature, 249, 845 (1974).

  22. 22

    Warner, D., Borthwick, P. W., and Steward, E. G., J. molec. Struct., 25, 397 (1975).

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  1. Department of Physics, The City University, London, EC1V 4PB, UK

    • E. G. STEWARD
    • , P. W. BORTHWICK
    • , G. R. CLARKE
    •  & D. WARNER

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https://doi.org/10.1038/256600a0

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