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Non-encephalitogenic antigen-induced suppression and reversal of allergic encephalomyelitis

Abstract

EXPERIMENTAL allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system1 induced in experimental animals by the myelin basic protein (BP)2 or specific peptide regions derived from the BP3 emulsified with Freund's complete adjuvant (FCA).

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References

  1. Paterson, P. Y., Adv. Immun., 5, 131–208 (1966).

    Article  CAS  Google Scholar 

  2. Eylar, E. H., Salk, J., Beveridge, G. C., and Brown, L. V., Archs Biochem. Biophys., 132, 34–48 (1969).

    Article  CAS  Google Scholar 

  3. Hashim, G. A., and Eylar, E. H., Archs Biochem. Biophys., 129, 645–654 (1969).

    Article  CAS  Google Scholar 

  4. Hashim, G. A., and Schilling, F. J., Biochem. biophys. Res. Commun., 50, 589–596 (1973).

    Article  CAS  Google Scholar 

  5. Hashim, G. A., Hwang, F., and Schilling, F. J., Archs Biochem. Biophys., 156, 298–309 (1973).

    Article  CAS  Google Scholar 

  6. Hashim, G. A., and Sharpe, R. D., Nature, 255, 484–485 (1975).

    Article  ADS  CAS  Google Scholar 

  7. Hashim, G. A., and Sharpe, R. D., Immunochemistry, 11, 633–640 (1974).

    Article  CAS  Google Scholar 

  8. Gutte, B., and Merrifield, R. B., J. biol. Chem., 246, 1922–1941 (1971).

    CAS  PubMed  Google Scholar 

  9. Hashim, G. A., and Eylar, E. H., Archs Biochem. Biophys., 129, 635–644 (1969).

    Article  CAS  Google Scholar 

  10. Eylar, E. H., and Hashim, G. A., Archs Biochem. Biophys., 131, 215–222 (1969).

    Article  CAS  Google Scholar 

  11. Benacerraf, B., and Daul, W. E., in Cellular Interaction in the Immune Response (edit. by Cohen, S., Cudkowicz, G. and McCluskey, R. T.), 298 (Karger, Basel, 1971).

    Google Scholar 

  12. Waksman, B. H., Arbuoys, S., and Arnason, B. G., J. exp. Med., 114, 997–1022 (1961).

    Article  CAS  Google Scholar 

  13. Paterson, P., in Immunological Diseases (edited by Santer, M.), 788 (Little, Brown and Co., Boston, 1965).

    Google Scholar 

  14. Alvord, E. C., Jr, Shaw, C., Hruby, S., and Kies, M. W., Ann. N.Y. Acad. Sci., 122, 333–345 (1965).

    Article  ADS  Google Scholar 

  15. Cunningham, V., and Field, E. J., Ann. N.Y. Acad. Sci., 122, 346–355 (1965).

    Article  ADS  CAS  Google Scholar 

  16. Einstein, E., Csejtey, J., Davis, W., and Rauch, H., Immunochemistry, 5, 567–575 (1968).

    Article  Google Scholar 

  17. Eylar, E. H., Jackson, J., Rothenberg, B., and Brostoff, S. W., Nature, 236, 74–76 (1972).

    Article  ADS  CAS  Google Scholar 

  18. Hashim, G. A., Sharpe, R. D., Carvalho, E., and Stevens, L. E., Proc. Soc. exp. Biol. Med., 149 (1975).

  19. Teitelbaum, D., Meshover, A., Hirshfeld, T., Arnon, R., and Sela, M., Eur. J. Immun., 1, 242–248 (1971).

    Article  CAS  Google Scholar 

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HASHIM, G. Non-encephalitogenic antigen-induced suppression and reversal of allergic encephalomyelitis. Nature 256, 593–595 (1975). https://doi.org/10.1038/256593a0

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  • DOI: https://doi.org/10.1038/256593a0

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